Chemistry: molecular biology and microbiology – Spore forming or isolating process
Patent
1990-02-21
1993-02-02
Chan, Y. Christina
Chemistry: molecular biology and microbiology
Spore forming or isolating process
435 7021, 5303883, C12N 522, C12P 2108, C07K 1528
Patent
active
051837552
ABSTRACT:
An anti-human papillomavirus (HPV) monoclonal antibody reactive with various types of HPVs, which is produced by a hybridoma comprising a fused cell of a mouse spleen cell from a mouse immunized with an alkali-treated HPV type 1 (HPV-1) and a mouse myeloma cell, and which is reactive with polypeptides of about 57 kilodaltons, about 160 kilodaltons and about 230 kilodaltons of HPV-1, and a process for preparing the same. The monoclonal antibody of the invention is reactive with various types of HPV and useful for diagnosis of various types of HPV infection (primary diagnosis).
REFERENCES:
patent: 4551270 (1985-11-01), Danos et al.
Chemical Patents Index, Basic Abstracts Journal (Derwent Publications Ltd) and partial English translation.
"Dako Rabbit Anti-Bovine Papillomavirus (BPV-1)", Dako Corporation, Catalog No. B580, p. 3.
Jenson et al., "Immunologic Relatedness of Papillomaviruses From Different Species", JNCI, vol. 64, No. 3, Mar. 1980, pp. 495-500.
Alberto Roseto, "Monoclonal antibodies to the Major Capsid Protein of Human Papillomavirus Type I", J. Gen. Virol., 65, 1984, pp. 1319-1324.
Cowsert et al., "Topographical and Conformational Epitopes of Bovine Papillomavirus Type 1 Defined by Monoclonal Antibodies", JNCI, vol. 79, No. 5, 1987, pp. 1053-1057.
Gerard Orth et al., "Evidence for Antigenic Determinants Shared by the Structural Polypeptides of (SHOPE) Rabbit Papillomavirus and Human Papillomavirus Type 1", Virology, 91, pp. 243-255.
The EMBO Journal, vol. 7, No. 3, 1988, pp. 822-833, Doorbar et al., "Analysis of HPV-1 E4 gene Expression using ipitopedifined antibodies".
Nakai et al., J. Gen. Virol., 68:189-1896, 1987.
Iwamoto Seiichi
Ohmoto Hiroshi
Chan Y. Christina
Futrovsky Susan L.
Kanebo Ltd.
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