Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1987-07-06
1990-09-18
Draper, Garnette
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
530388, 530387, 530390, 530391, 530808, 424 8591, 514885, C07K 1512, A61K 3900
Patent
active
049580094
ABSTRACT:
Immunotoxins comprising a cytotoxic moiety and monoclonal antibodies which bind to human ovarian cancer tissue having at least one of the following capabilities are claimed: cytotoxic ID.sub.50 of 10 nM or less against human ovarian cancer cells, retardation of human ovarian cancer tumor growth in mammals or extension of survival of a mammal carrying a human ovarian cancer tumor. Antigens to which the monoclonal antibody of the immunotoxin bind are identified and characterize the immunotoxins. Methods of killing human ovarian cancer cells, retarding the growth of human ovarian cancer tumors in mammals or extending the survival of mammals carrying human ovarian cancer tumors are claimed.
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Bjorn Michael J.
Fitzgerald David J.
Frankel Arthur E.
Laird Walter J.
Pastan Ira H.
Cetus Corporation
Draper Garnette
Fineman Elliott L.
Giotta Gregory J.
Halluin Albert P.
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