Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Monoclonal antibody or fragment thereof
Patent
1994-04-19
1996-12-31
Eisenschenk, Frank C.
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Monoclonal antibody or fragment thereof
43524027, 5303879, 5303882, 5303883, 5303891, 5303894, 935104, 935103, A61K 39395, C07K 1608, C12N 520, C12N 1506
Patent
active
055891748
ABSTRACT:
An anti-human influenza virus antibody is provided which recognizes the stem regions of haemagglutinin molecules of the H1N1 and H2N2 subtypes and has a neutralization activity, but does not recognize the stem region of the H3N2 subtype and has no neutralization activity. Also provided is an immunogenic artificial polypeptide having an antigenicity substantially the same as the stem regions of haemagglutinin molecules. Provided further is an immunogenic artificial polypeptide having an antigenicity substantially the same as the stem regions of haemagglutinin molecule and lacking the globular head region of haemagglutinin molecules. The antibody is useful in the diagnosis and treatment of influenza A virus, while the polypeptides are useful as a vaccine.
REFERENCES:
WPI Abstract of Japanese Patent Publication No. 59-501714 dated Oct. 11, 1994.
Green et al., Cell, 28, 477-487 (1982) "Immunogenic Structure of the Influenza Virus Hemagglutinin".
Okuno et al., Report on 1st China -Japan International Congress of Virology, pp. 47-48, (May 26-28, 1992), "Characterization of A Monoclonal Antibody Which Cross-Neutralized H1 and H2 Subtypes of Influenza A Virus".
Okuno et al., J. Virology, 67, No. 5, pp. 2552-2558, (May 1993) "A Common Neutralizing Epitope Conserved between the Hemagglutinins of Influenza A Virus H1 and H2 Strains".
Harns et al., Tibtech, 11:42, 1993.
Osband et al., Immunol. Today, 11:93, 1990.
Isegawa Yuji
Okuno Yoshinobu
Sasao Fuyoko
Ueda Shigeharu
Eisenschenk Frank C.
Takara Shuzo Co. Ltd.
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