Anti-human IGM immunoadsorbent and process for producing said im

Details Anti-human IGM immunoadsorbent and process for producing said im Anti-human IGM immunoadsorbent and process for producing said im

1986-11-21

1988-08-09

Yeung, James C.

Chemistry: molecular biology and microbiology

Carrier-bound or immobilized enzyme or microbial cell;...

435176, 436527, C12N 1100

Patent

active

047627875

ABSTRACT:
An immunoadsorbent material for removing IgM and IgM-complexes from biological fluids is prepared by covalently binding anti-IgM antibodies to a solid-phase silica matrix. It has been found that reacting hydroxyl-derivatized silica in the presence of a cyanogen bromide with the anti-IgM antibodies provides a particularly stable, high-capacity immunoadsorbent. The immunoadsorbent material may be employed in a column for therapeutic treatment of various disorders, such as primary biliary cirrhosis.

REFERENCES:
patent: 3652761 (1972-03-01), Weetall
patent: 4059685 (1977-11-01), Johnson
patent: 4163779 (1979-08-01), Harle et al.
patent: 4294817 (1981-10-01), Burgett et al.
patent: 4332783 (1982-06-01), Pernice et al.
patent: 4436823 (1984-03-01), Blumcke et al.
patent: 4478946 (1984-10-01), Vander Merwe et al.
patent: 4614513 (1986-09-01), Bensinger
patent: 4681870 (1987-07-01), Balint, Jr. et al.
Bensinger et al. (Jan. 1981) N. Engl. J. Med 304:160-162.
Bensinger et al. (Apr. 1982). N. Engl. J. Med. 306:935.
Bensinger et al. (Apr. 1982) J. Clin. Apheresis 1:2-5.
"Affinity Chromatography-Principles and Methods" published by Pharmacia Fine Chemicals, Uppsala, Sweden.
Weetal, "Immobilized Enzymes . . . Peptides", Publ. Marcel Dekker, Inc. N.Y., N.Y. (Jan. 1975) pp. 1-14.
Jones et al. (Apr. 1980) Cancer 46:675-684.
Ray et al (Apr. 1980) Cancer 45:2633-2638.
Holohan et al. (Apr. 1982) Can. Res. 42:3663-3668.
Terman et al. (Jan. 1981) N. Engl. J. Med. 305:1195-1200.
Balint, Jr. et al. (Apr. 1984) Cancer Research 44:734-743.
Weetal (Jan. 1976) Meth. Enzymol. 44:134-148.

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