Anti-human IGM immunoadsorbent and process for producing said im

Details Anti-human IGM immunoadsorbent and process for producing said im Anti-human IGM immunoadsorbent and process for producing said im

1988-05-13

1989-09-05

Kamen, Noah P.

Chemistry: molecular biology and microbiology

Apparatus

Bioreactor

435176, 436513, 436524, 436823, 530811, C12M 124

Patent

active

048638692

ABSTRACT:
An immunoadsorbent material for removing IgM and IgM-complexes from biological fluids is prepared by covalently binding anti-IgM antibodies to a solid-phase silica matrix. It has been found that reacting hydroxy-derivatized silica in the presence of cyanogen bromide with the anti-IgM antibodies provides a particularly stable, high-capacity immunoadsorbent. The immunoadsorbent material may be employed in a column for therapeutic treatment of various disorders, such as primary biliary cirrhosis.

REFERENCES:
patent: 3652761 (1972-03-01), Weetall
patent: 3975511 (1976-08-01), Vann et al.
patent: 4059685 (1977-11-01), Johnson
patent: 4163779 (1979-08-01), Harte et al.
patent: 4294817 (1981-10-01), Burgett et al.
patent: 4332783 (1982-06-01), Pernice et al.
patent: 4434227 (1984-02-01), Unger
patent: 4436823 (1984-03-01), Blumcke et al.
patent: 4478946 (1984-10-01), Van der Merwe
patent: 4614513 (1986-09-01), Bensinger
patent: 4681870 (1987-07-01), Balint, Jr. et al.
patent: 4705628 (1987-11-01), Yamamoto et al.
patent: 4716108 (1987-12-01), Sato et al.
Weetall (1971), Research Development, pp. 18-22, "Enzymes Immobilized on Inorganic Carriers".
Weetal, "Immobilized Enzymes . . . Peptides", Publ. Marcel Dekker, I NY, NY (1975), pp. 1-14.
Jones et al. (1980), Cancer, 46:675-684.
Ray et al. (1980), Cancer, 45:2633-2638.
Holohan et al. (1982), Can. Res., 42:3663-3668.
Terman et al. (1981), N. Engl. J. Med., 305:1195-1200.
Balint, Jr. et al. (1984), Cancer Research, 44:734-743.
Weetal (1976), Meth. Enzymol., 44:134-148.
Bensinger et al. (1981), N. Engl. J. Med., 304:160-162.
Bensinger et al. (1982), J. Clin. Apheresis, 1:2-5.
Bensinger et al. (1982), N. Engl. J. Med., 306:935.
"Affinity Chromatography-Affinity Chromatography-Principles and Methods" Published by Pharmacia Fine Chemicals, Uppsala, Sweden.

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