Anti-human IgE monoclonal antibodies

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...

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53038873, C07K 1642

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active

056250398

ABSTRACT:
Monoclonal antibodies are provided which specifically bind to human immunoglobulin e (IgE) and has a molecular weight of approximately 150,000 determined by SDS-polyacrylamide gel electrophoresis (non-reduced state), the ability to bind to human IgE-producing B cells, the ability to recognize IgE bound to human or canine cell having Fc.epsilon. receptor and further characterized by specific sequences.

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Bio/Technology, vol. 8, Feb. 1990, New York, USA, pp. 122-126, Chang et al., - "Monoclonal Antibodies Specific for Human IgE-Producting B Cells: A Potential Therapeutic . . . Allergic Diseases".
Nakajima et al. Allergy 44:187-191, 1989.
Chang et al., Biotechnology 8:122-127, 1990.
Vercelli et al. Nature 338:649-651, 1989.
Kabat et al. "Sequences of Proteins of Immunological Interest", 5th Edition US Dept. HHS pp. 163-200, 1991.

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