Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Animal cell – per se – expressing immunoglobulin – antibody – or...
Patent
1995-04-07
2000-01-04
Chin, Christopher L.
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
Animal cell, per se, expressing immunoglobulin, antibody, or...
435 74, 435 7021, 4351722, 435337, 435 25, 436548, 436811, 53038825, 53038826, 935104, 935110, C12N 520, G01N 33573, C07K 1640
Patent
active
060109033
ABSTRACT:
Disclosed is a monoclonal antibody which specifically reacts with active human ceruloplasmin as well as a method for diagnosing Wilson's disease using the same. The monoclonal antibody of the present invention specifically reacts with active human ceruloplasmin, it neutralizes the peroxidase activity of the active human ceruloplasmin upon binding thereto, and it does not specifically react with inactive human ceruloplasmin.
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Puchkova et al., "An Experiment for the Detection of the Wilson-Konovalov Mutation . . .", Author's Collective, 1989 Zh Nevropatol Psikhiatr IM SS Korsakova 89: 14-18.
Saenko et al, Mar. 1991. Immunoenzyme determination of total serum ceruloplasim Application to Wilson Disease. Biochemisty International 23(5):819-824.
Hiyamuta Shuichi
Kadota Akihiko
Shimizu Keiko
Chin Christopher L.
Grun James L.
Idemitsu Kosan Company Limited
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