Anti-human ceruloplasmin monoclonal antibody

Details Anti-human ceruloplasmin monoclonal antibody Anti-human ceruloplasmin monoclonal antibody

1993-03-11

1996-02-13

Saunders, David

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 794, 435 25, 43524027, 436518, 436536, 436548, 53038826, G01N 33573, G01N 33577

Patent

active

054910668

ABSTRACT:
Disclosed is a monoclonal antibody which specifically reacts with active human ceruloplasmin as well as a method for diagnosing Wilson's disease using the same. The monoclonal antibody of the present invention specifically reacts with active human ceruloplasmin, it neutralizes the peroxidase activity of the active human ceruloplasmin upon binding thereto, and it does not specifically react with inactive human ceruloplasmin.

REFERENCES:
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patent: 4780401 (1988-10-01), Heusser et al.
Megrabian et al, 1990, [Monoclonal Antibodies to Ceruloplasmin and Their Use for Immunoenzyme Assay of This Protein]. Biokhimiia 55: 361-7.
Saenko et al, Mar. 1991. Immunoenzyme Determination of Total Serum Ceruloplasmin. Application to Wilson Disease. Biochem. Int. 23: 819-24.
Puchkova et al, 1989. [An Experiment for the Detection of the Wilson-Konovalov Mutation Heterozygote on the Basis of an Investigation of the Molecular Forms of Ceruloplasmin] Zh Nevropatol Psikhiatr Im SS Korsakova 89: 14-18.
Matsuda et al, 1974, Determination of Apoceruloplasmin by Radioimmunoassay in Nutritional Copper Deficiency, Menkes' Kinky Hair Syndrome, Wilson's Disease, and Umbilical Cord Blood. Ped. Res. 8: 821-4.
Hellstrom et al, 1985, in "Monoclonal Antibodies for Cancer Detection and Therapy" (R. W. Baldwin, ed) Academic Press, London. p. 20.
Shaposhnikov et al, 1969, Identification of Ceruloplasmin in Human Liver Cells by Fluorescent Antibodies and Absence of This Protein in Wilson Disease. Experientia 25: 424-6.
Hudson et al, 1980. Practical Immunology. Blackwell Scientific Publications, Oxford, p. 120.
Saenko et al, Abstract 92082901, 56(9), pp. 1640-1646 (1991).
Megrabian et al, Abstract 90254217, 55(2), pp. 361-367 (1990).
Puchkova et al, Biological Abstracts, vol. 90, No. 50705 (1990).
Abstract of JP6268987--"Anti-human Ceruloplasmin Monoclonal Antibody, Used in Diagnosis of Liver Diseases, Wilson's Disease, etc. . . . ".
Schosinsky, et al. (1974) Clin. Chem 20(12):1556-1563.
36th Japan Human Genetics Society (1991); abstract.

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