Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1998-11-24
2000-12-12
Huff, Sheela
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
53038885, 5303871, 5303873, 5303888, 4241331, 4241561, 4241301, 4241351, 4241411, 4241431, C07K 1628
Patent
active
061600997
ABSTRACT:
This invention relates to novel humanized and other recombinant or engineered antibodies or monoclonal antibodies to a human .alpha..sub.v subunit-containing heterodimeric integrin receptors and to the genes encoding same. Such antibodies are useful for the therapeutic and/or prophylactic treatment of disorders mediated by such receptors, such as cancer, in human patients.
REFERENCES:
patent: 5985278 (1999-11-01), Mitjans et al.
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Amit et al., Science 233:747-733, 1986.
Rudikoff et al., Proc. Natl. Acad. Sci. USA 79:1979-83, 1982.
Ross et al., Interations Between the Bone Matrix Proteins Osteopontin and Bone Sialoprotein and the Osteoclast Integrin Alpha v Beta 3 Potentiate Bone Resorption, J. Biol. Chem., vol. 268 (13), pp. 9901-9907 (1993).
Brown et al., "Stimulation of Migration of Human Aortic Smooth Muscle Cells by Vitronectin: Implications for Atherosclerosis", Cardiovascular Reserch, vol. 28, pp. 1815-1820 (1994).
Choi et al., "Inhibition of Neointimal Hyperplasia by Blocking .alpha..sub.v .beta..sub.3 Integrin with a Small Peptide Antagonist GpenGRCDSPCA", Journal of Vascular Surgery, vol. 19, pp. 125-134 (1994).
Brooks et al., "Integrin .alpha..sub.v .beta..sub.3 Antagonists Promote Tumor Regression by Inducing Apoptosis of Angiogenic Blood Vessels", Cell, vol. 79, pp. 1157-1164 (1994).
Cheresh et al., A Novel Vitronectin Receptor Integrin (.alpha..sub.v .beta..sub.x) is Responsible for Distinct Adhesive Properties of Carcinoma Cells, Cell, vol. 57, pp. 59-69 (1989).
Johanson Kyung O
Jonak Zdenka Ludmila
Taylor Alexander
Trulli Stephen H
Baumeister Kirk
Helms Larry R.
Huff Sheela
King William T.
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