Anti-HIV ribozymes

Details Anti-HIV ribozymes Anti-HIV ribozymes

1996-09-25

1998-04-21

Le Guyder, John

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Primate cell, per se

435 6, 435 9131, 4351723, 4353201, 435325, 435366, 536 231, 536 232, 536 245, C12N 1585, C12Q 168

Patent

active

057417067

ABSTRACT:
GUC and GUA ribozymes which cleave HIV RNA are provided. The ribozymes cleave HIV RNA in vitro and in vivo. When the ribozymes are expressed in cells, they inhibit HIV replication in the cells.

REFERENCES:
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Yu, et al., Virology (1995), In Vitro and in Vivo Characterization of a Second Functional Hairpin Ribozyme Against HIV-1, 206:381-386.
Yu, et al. (1995) Proc. Natl. Acad. Sci. USA, Intracellular Immunization of Human Fetal Cord Blood Stem/Progenitor Cells with a Ribozyme Against Human Immunodeficiency Virus Type 1, 92:699-703.
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