Anti-HIV proteins GAP 31, DAP 30 and DAP 32 and therapeutic uses

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

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514 12, 514885, 530370, 530377, 5303871, 530395, C07K 1300, C07K 1510, C07K 1514

Patent

active

053170091

ABSTRACT:
New proteins, termed GAP 31, obtainable from the seeds of Gelonium multiflorum, and DAP 30 and DAP 32, obtainable from the leaves or seeds of Dianthus caryophyllus, or the above proteins produced by recombinant means, are useful for treating HIV infections. In treating HIV infections, the protein is administered alone or in conjunction with other anti-HIV therapeutics. Also provided are processes for purifying the proteins, DNA sequences encoding the proteins, hosts expressing the proteins, recombinant DNA methods for expressing the proteins, and antibodies specific for the proteins.

REFERENCES:
patent: 4795739 (1989-01-01), Litson et al.
Ho, et al (1991) Biochimica Biophysica Acta 1088: 311-314.
Goodman in Basic and Clinical Immunology, 5th ed. (Stites, et al., eds.) Lange Medical Publications, Los Altos, Calif., 1984, pp. 21-22.
Lee-Huang, et al (1991) FEBS Letters 291 (1): 139-144.
Montecucchi, et al (1989) Int. J. Peptide Protein Res 33: 263-267.
Goldmacher, et al (Oct. 1989) Journal of Cellular Physiology 141 (1): 222-234.
Sivam, et al (Jun. 15, 1987) Cancer Research 47: 3169-3173.

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