Anti-HIV peptide and modified anti-HIV peptide

Details Anti-HIV peptide and modified anti-HIV peptide Anti-HIV peptide and modified anti-HIV peptide

1990-07-02

1991-08-27

Lee, Lester L.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

25 or more amino acid residues in defined sequence

A61K 3702, C07K 710

Patent

active

050434225

ABSTRACT:
A peptide having anti-HIV activity consists of an amino acid chain represented by Asn-Phe-Pro-Leu-Ile-Ile-Lys-Asn-Leu-Lys-Ile-Glu-Asp-Ser-Asp-Thr-Tyr-Ile-Cy s-Glu-Val-Glu-Asp-Gln-Lys-Glu. The Cys underlined in the above amino acid chain may be replaced by Phe, Ser, Cys.sup.Acm or Cys.sup.Bzl.

REFERENCES:
patent: 4812556 (1989-03-01), Vahlne et al.
patent: 4868287 (1989-09-01), Sikes et al.
patent: 4956273 (1990-09-01), Kennedy et al.
patent: 4957737 (1990-09-01), Heimer et al.
patent: 4983387 (1991-01-01), Goldstein et al.
The Journal of Immunology, "Binding of the Human Retrovirus HTLV-III/LAV/ARV/HIV to the CD(T) Molecule", McDougal et al., vol. 137, pp. 2937-2944, 11/86.
Science, "Synthetic CD Peptide Derivatives that Inhibit HIV Infection and Cytopathicity", pp. 712-716, 8/88, Lifson et al.

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