Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Reexamination Certificate
2004-03-09
2010-02-23
Mosher, Mary E (Department: 1648)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
C424S141100, C435S005000, C435S070210, C435S339100, C530S388150
Reexamination Certificate
active
07667006
ABSTRACT:
The present invention aims at providing a high affinity anti-HIV antibody. According to the present invention, there are provided an antibody or a fragment thereof that binds to the gp12 glycoprotein of HIV and has a dissociation constant (KD) value of 1.0×10−9(M) or less; a pharmaceutical composition comprising the antibody or fragment thereof; and a method of producing an anti-HIV antibody or a fragment thereof, comprising immunizing a GANP transgenic non-human mammal or a progeny thereof with a polypeptide consisting of the amino acid sequence as shown in SEQ ID NO: 6 as an antigen and collecting the antibody from the resultant mammal or progeny.
REFERENCES:
Hunsmann, et al. Structural and epidemiological features of primate lymphotropic retroviruses. Princess Takamatsu Symp. 1984;15:109-18.
Laman, et al. Variant-Specific Monoclonal and Group-Specific Polyclonal Human Immunodeficiency Virus Type 1 Neutralizing Antibodies Raised with Synthetic Peptides from the gpI20 Third Variable Domain. J. Virol. 1992; 66(3):1823-1831.
Okamoto, et al. In SCID-hu Mice, Passive Transfer of a Humanized Antibody Prevents Infection and Atrophic Change of Medulla in Human Thymic Implant due to Intravenous Inoculation of Primary HIV-1 Isolate. Journal of Immunology, 1998, 160: 69-76.
Boudet, et al. Anti-Idiotypic Antibodies to the Third Variable Domain of gp120 Induce an Anti-HIV-I Antibody Response in Mice. Virology. 1994;200:176-188.
Laman J.D. et al., Journal of Virology, Mar. 1992, vol. 66, No. 3, pp. 1823 to 1831.
Boudet F. et al., Virology, 1994, vol. 200, No. 1, pp. 176 to 188.
Abe E. et al., Gene, 2000, vol. 255, No. 2, pp. 219 to 227.
Kazuhiko Kuwabara, Molecular Medicine, special extra issu, Men'eki 2004, Dec. 10, 2003, vol. 40, pp. 40 to 48.
J. S. McDougal et al.,Science, vol. 231, Jan. 24, 1986, pp. 382-385.
Kuwahara Kazuhiko
Minoda Chiemi
Sakaguchi Nobuo
Birch & Stewart Kolasch & Birch, LLP
Kumamoto Technology and Industry Foundation
Mosher Mary E
Snyder Stuart W
LandOfFree
Anti-HIV antibody does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Anti-HIV antibody, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Anti-HIV antibody will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4229215