Anti-HIV and anti-tumor peptides and fragments of lysozyme

Details Anti-HIV and anti-tumor peptides and fragments of lysozyme Anti-HIV and anti-tumor peptides and fragments of lysozyme

2001-07-09

2010-11-23

Kim, Taeyoon (Department: 1651)

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

C424S094610, C424S188100, C424S094600, C424S094100, C435S200000, C435S195000, C435S183000

Reexamination Certificate

active

07838275

ABSTRACT:
A fragment of lysozyme which contains a minimum nine amino acid sequence with antiviral, anti-tumor and bactericidal activities but lacking muramidase activity is provided. The invention also relates to pharmaceutical compositions containing this fragment and methods for treating HIV infection or for inhibiting tumor growth using this fragment as an active ingredient.

REFERENCES:
patent: 5554501 (1996-09-01), Coassin
patent: 5583211 (1996-12-01), Coassin et al.
patent: 5919639 (1999-07-01), Humphreys et al.
patent: 06-211692 (1994-08-01), None
patent: WO 95/09176 (1995-04-01), None
patent: WO 95/11912 (1995-05-01), None
patent: WO 98/26747 (1998-06-01), None
patent: WO 00/57920 (2000-10-01), None
Laible et al. Bactericidal activity of human lysozyme, muramidase-inactive lysozyme, and cationic polypeptides againstStreptococcus sanguisandStreptococcus faecalis: inhibition by chitin oligosaccharides. Infect Immun. Jun. 1985;48(3):720-8.
Burkitt. 1999 Treatment Briefs: Pregnant Women's Urine Analyzed for Antiviral Agents. Treatment Issues: Newsletter of Experimental AIDS Therapies—vol. 13, No. 3.
Huang et al. 2000 Identification, characterization and synthesis of lysozyme mimetics with potent anti-HIV activity.
NCBI sequence viewer for lysozyme (http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&val=1335210).
NCBI sequence viewer for lysozyme precursor, http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&val=4557894.
Chen. HC 2005 Structure and function of peptide and protein hormones (NICHD, NIH Annual report 2005) (http://eclipse.nichd.nih.gov
ichd/annualreport/2005/errb/umspc.htm).
Pellegrini et al. 1997 Identification and isolation of a bactericidal domain in chicken egg white lysozyme. J. Appl. Microbiol. 82:372-378. Abstract only.
Gait and Karn. Progress in anti-HIV structure-based drug design. TIBTECH. 1995. vol. 13, pp. 430-438.
Perrin and Telenti. HIV Treatment Failure: Testing for HIV Resistance in Clinical Practice. Science vol. 280. Jun. 19, 1998. p. 1871-1873.
Yarchoan and Broder. Correlations between the in vitro and in vivo activity of anti-HIV agents: implications for future drug development. J. Enzyme Inhibition. 1992. vol. 6, pp. 99-111.

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