Anti-HIV agent

Details Anti-HIV agent Anti-HIV agent

1992-08-17

1993-10-26

Wityshyn, Michael G.

Drug, bio-affecting and body treating compositions

Lymphokine

530362, 530363, 530382, 5303871, 530394, A61K 3702

Patent

active

052564126

ABSTRACT:
The invention relates to an anti-HIV agent comprising as an effective component a plasma protein of which the polarity of the amino group of the amino acid residue constituting the plasma protein is chemically modified into a negative moiety by a carboxylic acid, for example, by maleic anhydride or succinic anhydride. Plasma proteins modified with dicarboxylic anhydride, which are the effective components of the anti-HIV agent of this invention, inhibit the formation of large cells in mixed culturing of HIV infected cells and non-infected cells as well as the direct infection of helper T cells with HIV. They are very safe compounds and are expected to be applicable to the treatment of HIV infected patients

REFERENCES:
Jonas et al. Biochemistry vol. 9, No. 24, (1970) pp. 4729-4735.
Butler et al. Method Enzymol., 25, (1972) pp. 191-199.

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