Anti-HIV achiral polyurea oligomers, a process for creating them

Details Anti-HIV achiral polyurea oligomers, a process for creating them Anti-HIV achiral polyurea oligomers, a process for creating them

1993-12-27

1998-03-17

Kelly, C. H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

564 50, 564 51, 564 52, 564 53, 574588, 574595, C07C27300, C61K 3117

Patent

active

057288747

ABSTRACT:
The present invention relates to achiral polyurea oligomers, their uses and formulations as anti-HIV pharmaceuticals and to a process for the preparation of narrow mono- and polydispersed oligomers as an emodiment of the invention. The achiral oligomers are derived from repeating units of the monomer 4,4'-diamino-biphenyl-3,3'-disulfonic acid and are water soluble, have a rigid backbone, possess ordered anionic spacing and have a number average molecular weight of <20,000. The process relates to the synthesis of narrow poly- and mono-dipersed oligomers comprising the steps of: 1) restricting the crude olydispersed anionic oligomer mixture to a narrow polydispersed anionic oligomer mixture to a narrow polydispersed anionic oligomer mixture; and/or 2) isolating the monodispersed anionic oligomer; and 3) optionally converting the narrow poly- or mono-dispersed anionic oligomer salt from Step 1 or 2 to a desired pharmaceutically-acceptable salt, especially a solim or potassium salt. The process steps may be executed whereby step 1 or 2 is done alone, each in combination with Step 3, or all three steps are done.

REFERENCES:
patent: 2833744 (1958-05-01), Neher
patent: 3528949 (1970-09-01), Rutledge
patent: 4104262 (1978-08-01), Schade
patent: 4107202 (1978-08-01), Conrow et al.
patent: 4328244 (1982-05-01), Daniel et al.
patent: 4349568 (1982-09-01), Markley et al.
patent: 4471110 (1984-09-01), Christell
patent: 4604404 (1986-08-01), Munson et al.
patent: 4736014 (1988-04-01), Engelhardt et al.
patent: 4783446 (1988-11-01), Neushul
patent: 4824916 (1989-04-01), Kershner et al.
patent: 4895660 (1990-01-01), Kershner et al.
patent: 4966894 (1990-10-01), Herr et al.
patent: 5276182 (1994-01-01), Cardin et al.
patent: 5424063 (1995-06-01), Cardin et al.
*Amer Chem Soc Symp Ser, "Biological Activities of Polymers" No. 182, pp. 205-220, (1982).
*Principles of Polymerization, 2d, pp. 20-25, G. Odian (1981).
*Protein Purification, pp. 186-198 (1987) R. K. Scopes.
*Polymer Fractionation, pp. 43-65, (1967) A. KoterA.
*Polymer Fractionation, p. 462, (1967).
*J. Chrom. Library, 41A, pp. A127-A208, A303-A399. (1985).
*Protein Purification, pp. 199-215, (1987) R. K. Scopes.
*Dowex: Ion Exchange, the Dow Chemical Company, (1958), pp. 39-66.
*Macromolecules, V. 1, Ch. 8, (1984).
P.M. Rosoff et al., J. Med. Chem 263(36), 19535-19540 (1973).
C&E News, p. 11 (Jul. 16, 1990).
Chem. Abstracts, polyamides vol. 102, No. 62707 (1985), Toshiba Corp., Japan, "Block Copolymers" JP 59179521 A2 841012.
Antiviral Research, 18(1992), Sulfonic acid polymers as a new class of human immunodefic-ciency virus inhibitors, Prem Mohan, et al., pp. 139-150.
Komp et al, Chemical Abstracts vol. 110 Abstract No. 33727k (1989).
Hofferek et al., Chemical Abstracts vol. 114: 180333q (1990).
Berge et al., J Pharm. Sciences 66(1), pp. 1-19, 1977.
Vandenberg E.J. et al., Polymeric Matericals Science and Engineering, vol. 57, Fall Meeting 1987, pp. 139-143.

Affiliated with

Also associated with

Rating

Anti-HIV achiral polyurea oligomers, a process for creating them does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Anti-HIV achiral polyurea oligomers, a process for creating them, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Anti-HIV achiral polyurea oligomers, a process for creating them will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-959113