Organic compounds -- part of the class 532-570 series – Organic compounds – Unsubstituted hydrocarbyl chain between the ring and the -c-...
Patent
1993-04-05
1993-12-14
Shah, Mukund J.
Organic compounds -- part of the class 532-570 series
Organic compounds
Unsubstituted hydrocarbyl chain between the ring and the -c-...
C07D48708, A61K 3155
Patent
active
052704645
ABSTRACT:
Novel tetrahydroimidazo[1,4]benzodiazepin-2-(thi)ones possessing anti-HIV-1 activity, compositions containing these compounds as active ingredients, and methods of treating subjects suffering from HIV-1 infection by administering these compounds. The compounds have the basic structure shown in Formula (I): ##STR1##
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P. Geneste et al., Eur. J. Med. Chem.-Chimica Therapeutica, Jan.-Feb., 1978-13, No. 1, pp. 53-59.
Pauwels et al., Nature, vol. 343, Feb. 1, 1990, pp. 470-474.
Koyanagi et al., Int. J. Cancer: 36, 445-451 (1985).
Breslin Henry J.
Janssen Paul A. J.
Kukla Michael J.
Raeymaekers Alfons H. M.
Van Gelder Josephus L. H.
Datlow Philip I.
Janssen Pharmaceutica N.V.
Metz Charles J.
Shah Mukund J.
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