Anti-hepcidin antibodies and uses thereof

Details Anti-hepcidin antibodies and uses thereof Anti-hepcidin antibodies and uses thereof

2008-10-29

2010-10-26

Huff, Sheela J (Department: 1643)

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Structurally-modified antibody, immunoglobulin, or fragment...

C530S387300, C435S007100

Reexamination Certificate

active

07820163

ABSTRACT:
Monoclonal antibodies are provided that selectively bind human hepcidin-25 and are characterized as having high affinity for human hepcidin-25 and strong human mature hepcidin neutralizing properties. The antibodies of the invention are useful therapeutically for increasing serum iron levels, reticulocyte count, red blood cell count, hemoglobin, and/or hematocrit in a human and for the treatment and diagnosis of mature hepcidin-promoted disorders such as anemia, in a human subject.

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