Anti hCG-.beta. core monoclonal antibody, its production and use

Details Anti hCG-.beta. core monoclonal antibody, its production and use Anti hCG-.beta. core monoclonal antibody, its production and use

1993-04-12

1996-03-26

Scheiner, Toni R.

Chemistry: analytical and immunological testing

Involving production or treatment of antibody

Monoclonal antibody

435 792, 435 793, 435 794, 435 7021, 4351722, 43524027, 436528, 436534, 436813, 436817, 53038824, 5303911, 5303913, G01N 3353, C12N 520, C07K 1626

Patent

active

055019889

ABSTRACT:
A hybridoma capable of producing monoclonal antibody for recognizing hCG-.beta. core region and hCG-.beta. subunit, which is obtained by cell fusion of an antibody producing cell of a mammal immunized with hCG-.beta. subunit and a lymphoid cell line, and the monoclonal antibody are disclosed. The monoclonal antibody can be used in an immunochemical determination method useful for diagnosis of cancers.

REFERENCES:
Norman et al. J. Clin. Endocrin. Metab. vol. 61., No. 6, pp. 1031-1038. (1985).
Cole et al., Molecular Endocrinology, vol. 2, No. 9, 825-830 (1988).
Bidart et al., J. Biol. Chem., vol. 262, No. 18, 8551-8556 (1987).
Chemical Abstracts 113:34783z (1990).
Ryuuichi Nishimura et al., 9th Meeting of Study Group of Tumor Markers, Program and Abstracts of Presentation, Nagoya, Japan, Oct. 22, 1989 (with translation).
Steven Birken et al., Endocrinology, 123, 572-583, 1988.
Alexander Krichevsky et al., Endocrinology, 123, 584-593, 1988.
H. R. Masure et al., Journal of Clinical Endocrinology and Metabolism, 53, 1014-1020, 1981.
Laurence A. Cole et al., Cancer Research, 48, 1356-1360, 1988.

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