Anti-HBs monoclonal antibody

Details Anti-HBs monoclonal antibody Anti-HBs monoclonal antibody

2011-01-18

2011-01-18

Peng, Bo (Department: 1648)

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Monoclonal antibody or fragment thereof

C424S142100, C424S133100, C530S388150, C530S388300, C530S388100

Reexamination Certificate

active

07871621

ABSTRACT:
An anti-HBs monoclonal antibody is described herein. This antibody can bind to the following: (i) a wild type HBsAg; (ii) at least one mutant HBsAg selected from the group consisting of a first mutant HBsAg and a second mutant HBsAg; and (iii) at least one mutant HBsAg selected from the group consisting of a third mutant HBsAg and a fourth mutant HBsAg. The first mutant HBsAg has a mutation at position 120. The second mutant HBsAg has a mutation at position 141. The third mutant HBsAg has a substitution to a lysine at position 118. The fourth mutant HBsAg has only one mutation at position 144 and an amino acid at the position 144 is substituted by a glutamic acid.

REFERENCES:
patent: 5856084 (1999-01-01), Karayiannis et al.
patent: 6030616 (2000-02-01), Waters et al.
patent: 2004/0219154 (2004-11-01), Jolivet-Reynaud et al.
patent: WO 97/40164 (1997-10-01), None
patent: WO 97/40164 (1997-10-01), None
Karthiggesu V. et al. “A hepatitis B virus variant found in the sera of immunised children induces a conformational change in the HBsAg “a” determinant”. J Med Virol. Aug. 1999;58(4):346-52.
Paulij WP et al “Localization of a unique hepatitis B virus epitope sheds new light on the structure of hepatitis B virus surface antigen”. J Gen Virol. Aug. 1999;80 ( Pt 8):2121-6.
Jolivet-Reynaud et al, “Localization of Hepatitis B Surface Antigen Epitopes Present on Variants and Specifically Recognised by Anti-Hepatitis B Surface Antigen Monoclonal Antibodies”, Journal of Medical Virology, vol. 65, No. 2, Oct. 2001, pp. 241-249, XP002195005.
Cooreman et al, “Characterization of the Reactivity Pattern of Murine Monoclonal Antibodies Against Wild-Type Hepatitis B Surface Antigen to G145R and Other Naturally Occuring “a” Loop Escape Mutations”, Heptatology, vol. 30, No. 6, Nov. 1999, pp. 1287-1292, XP001015475.
Mengji Lu, et al, “De Novo Infection in a Renal Transplant Recipient Caused by Novel Mutants of Hepatitis B Virus Despite the Presence of Protective Anti-Hepatitis B Surface Antibody”, Journal of Infectous Diseases, vol. 187, Apr. 15, 2003, pp. 1323-1326.
Klaus M. Weinberger, et al, “High Genetic Variability of the Group-Specific α-Determinant of Hepatitis B Virus Surface Antigen (HBsAg) and the Corresponding Fragment of the Viral Polymerase in Chronic Virus Carriers Lacking Detectable HBsAg in Serum”, Journal of General Virology, vol. 81, 2000, pp. 1165-1174.

Affiliated with

Also associated with

Rating

Anti-HBs monoclonal antibody does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Anti-HBs monoclonal antibody, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Anti-HBs monoclonal antibody will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2711810