Anti-gram-positive bacterial methods and materials

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

514 21, 514152, 514192, 424114, 530350, A61K 3816, A61K 3817

Patent

active

057835616

ABSTRACT:
The present invention relates to methods of treating gram-positive bacterial infections by administration of a BPI protein product alone, or in combination with an antibiotic. BPI protein product alone has a bactericidal or growth inhibitory effect on selected gram-positive organisms. BPI protein product also increases the susceptibility of gram-positive organisms to antibiotics and can even reverse resistance of gram-positive organisms to antibiotic.

REFERENCES:
patent: 5089274 (1992-02-01), Marra et al.
patent: 5171739 (1992-12-01), Scott
patent: 5198541 (1993-03-01), Elsbach et al.
patent: 5234912 (1993-08-01), Marra et al.
patent: 5308834 (1994-05-01), Scott et al.
patent: 5334584 (1994-08-01), Scott et al.
patent: 5348942 (1994-09-01), Little, II et al.
Bamberger, et al. "Microbial Etiology and Clinical Characteristics of Distributive Shock", Clinical Infections Diseases, 18:726-30, (1994).
Bone, "Gram-positive Organisms and Sepsis", Arch. Intern. Med., 154910:26-34 (Jan. 10, 1994).
Bone, "How Gram-Positive Organisms Cause Sepsis", J. Critical Care, 8(1):51-59 (Mar. 1993).
Dahmash, et al., "Septic shock in critically ill patients: aetiology, management and outcome", J. Infection26:159-170 (1993).
Dal Nogare, "Southwestern Internal Medicine Conference: Septic Shock", Am. J. Med. Sciences, 302(1):50-65 (Jul. 1991).
Davies, "Inactivation of Antibiotics and the Dissemination of Resistance Genes", Science, 264:375-381 (Apr. 15, 1994).
Eliopoulos and Moellering, "Antimicrobial Combinations", In Antibiotics in Laboratory Medicine, 3rd ed., pp. 432-492, (Lorian ed., Baltimore, MD) (1991).
Elsbach, "Antibiotics from within: Antibacterials from Human and Animal Sources", Trends. Biotech, 8(1):26-30 (Jan. 1990).
Elsbach and Weiss, "Oxygen-independent Antimicrobial Systems of Phagocytes," in Inflammation: Basic Principles And Clinical Correlates, pp. 603-636, (Gallin et al eds., Raven Press, Ltd.) (1992).
Elsbach and Weiss, "Oxygen-Independent Bactericidal Systems of Polymorphonuclear Leukocytes", in Advances in Inflammation Research, vol. 2, pp. 95-113 (Weissmann ed., Raven Press, Ltd.) (1981).
Elsbach et al., "Separation and Purification of a Potent Bactericidal/Permeability-Increasing Protein and a Closely Associated Phospholipase A.sub.2 from Rabbit Polymorphonuclear Leukocytes", J. Biol. Chem., 254(21):11000-11009 (Nov. 10, 1979).
Fry et al., "Nosocomial Blood-borne Infection Secondary to Intravascular Devices", Am. J. Surg., 167(2):268-272 (Feb. 1994).
Gabay, "ubiquitous Natural Antibiotics", Science, 264:373-374 (Apr. 15, 1994).
Gazzano-Santoro et al., "High-Affinity Binding of the Bactericidal/Permeability-Increasing Protein and a Recombinant Amino-Terminal Fragment to the Lipid A Region of Lipopolysaccharide", Infect. Immun., 60(11):4754-4761 (Nov. 1992).
Gray et al., "Bactericidal Activity of Synthetic Peptides Based on the Structure of the 55-Kilodalton Bactericidal Protein from Human Neutrophils", Infect. Immun., 60(7): 2732-2739 (Jul. 1994).
Gray et al., "Cloning of the cDNA of a Human Neutrophil Bactericidal Protein", J. Biol. Chem., 264(16):9505-9509 (Jun. 5, 1989).
Hackshaw, et al., "Naloxone in septic shock", Critical Care Med., 18(1):47-51 (1990).
Heumann et al., "Gram-Positive Cell Walls Stimulate Synthesis of Tumor Necrosis Factor Alpha and Intrleukin-6 by Human Monocytes", Infect. Immun., 62(7):2715-2721 (Jul. 1994).
Johansson et al., "Septicemia in Granulocytopenic Patients: A Shift in Bacterial Etiology", Scand J. Infect. Dis, 24:357-360 (1992).
Kadurugamuwa et al., "Interaction of Gentamicin with the A Band and B Band Lipopolysaccharides of Pseudomonas aeruginosaand Its Possible Lethal Effect", Antimicrobial Agents and Chemotherapy, 37(4):715-721 (Apr. 1993).
Kessler et al., "Bacteremia in Patients on Chronic hemodialysis", Nephron, 64(1):95-100 (1993).
Kingman, "Resistance a European Problem, Too", 264:363-365 (Apr. 15, 1994).
Lautenschlager, et al. "Course and Outcome of Bacteremia Due to Staphylococcus aureus; Evaluation of Different Clinical Case Definitions", Clinical Infectious Diseases, 16;567-73(1993).
Levy et al., "Antibacterial 15-kDa Protein Isoforms (p15s) are Members of a Novel Family of Leukocyte Proteins", J. Biol. Chem., 268(8):6058-6068 (Mar. 16, 1993).
Mannion et al., "Preferential Binding of the Neurophil Cytoplasmic Granule-Derived Bactericidal/Permeability Increasing Protein to Target Bacteria", J. Clin. Invest., 142(8):2807-2812 (Apr. 15, 1989).
Mannion et al., "Separation of Sublethal and Letha effects of Polymorphonuclear Leukocytes on Escherichia coli ", J. Clin. Invest., 86:631-641 (Aug. 1990).
Mannion et al., "Separation of Sublethal and Lethal Effects of the Bactericidal/Permeability Increasing Protein on Escherichia coli ", J. Clin. Invest., 85:853-860 (Mar. 1990).
Moon et al., "Monoclonal Antibodies Provide Protection Against Acular Pseudomonas aeruginosaInfection", Invest Ophthalmol & Vis Sci., 29(8):1277-1284 (1988).
Nikaido, "Prevention of Drug Access to Bacterial Targets; Permeability Barriers and Active Efflux", Science, 264:382-387 (Apr. 15, 1994).
Ooi et al., "A 25-kDa NH.sub.2 --terminal Fragment Carries All the Antibaterial Activities of the Human Neutrophil 60-kDa Bacericidal/permeability-increasing protein", J. Biol. Chem., 262(31):14891-14894 (1987).
Ooi et al.,"Endotoxin-neutralizing properties of the 25 kD N-Terminal Fragment and a Newly Isolated 30 kD C-Terminal Fragment of the 55-60 kD Bactericidal/Permeability-Increasing Protein of Human Neutrophils", J. Exp. Med., 174;649-655 (Sep. 1991).
Ooi et al., "Isolation of Two isoforms of a Novel 15-kDa Protein from Rabbit Polymorphonuclear Leukocytes that Modulate the Antibacterial Actions of Other Leukocyte Proteins, "J. Biol. Chem, 265:15956-15962 (1990).
Spratt, "Resistance to Antibiotics Mediated by Target Alterations", Science, 264:388-393 (Apr. 15, 1994).
Stratton, "In Vitro Testing: Correlations Between Bacterial Suspectibility, Body Fluid Levels and Effectiveness of Antibacterial Therapy", in Antibiotics in Laboraory Medicine, pp. 849-879 (Lorian ed., Williams & Wilkins) (1991).
Sugar et al., "Treatment of Experimental Pseudomonas Corneal Ulcers with Enoxacin, a Quinolone Antibiotic", Arch Ophthalmol., 104:1230-1232 (Aug. 1986).
Taber et al., "Bacterial Uptake of Aminoglycoside Antibiotics", Microbiological Reviews, 51(4):439-457 (Dec. 1987).
Travis, "Reviving the Antibiotic Miracle", Science, 264:360-362 (Apr. 15, 1994).
Vaara, "Agents that Increase the Permeability of the Outer Membrane", Microbiological Reviews, 56(3):395-411 (Sep. 1992).
Veld et al., "Effects of the Bactericidal/Permeability-Increasing Protein of Polymorphonuclear Leukocytes on Isolated Bacterial Cytoplasmic Membrane Vesicles", Infect. Immun., 56(5):1203-1208 (May 1988).
Vindenes et al., "The Frequency of Bacteremia and Fungemia Following Wound Cleaning and Excision in Patients with Large Burns", J. Trauma, 35(5):742-749 (Nov. 1993).
Watanakunakorn et al., "Alpha-hemolytic Streptococcal Bacteremia: A Review of 203 Episodes during 1980-1991", Scand. J. Infect. Dis., 2594):403-408 (1993).
Watanakunakorn et al., "Pneumococcal Bacteremia in Three Community Teaching Hospitals From 1980 to 1989", Chest, 103(4):1152-56 (1993).
Weiss and Olsson, "Cellular and Subcellular Localization of the Bactericidal/Permeability-Increasing Protein of Neutrophils", Blood, 69(2):652-659 (Feb. 1987).
Weiss et al., "Human Bacericidal/Permeability-Increasing Protein and a Recombinant NH.sub.2 -Terminal Fragment Cause Killing of Serum-resistant Gram-negative Bacteria in Whole Blood and Inhibit Tumor Necrosis Factor Release Induced by the Bacteria", J. Clin. Invest., 90:1122-1130 (Sep. 1992).
Weiss et al., "Resistance of Gram-negative Bacteria to Purified Bactericidal Leukocyte Proteins", J. Clin. Invest., 65:619-628 (Mar. 1980).
Weiss et al., "The Role of Lipopolysaccharides in the Action of the Bactericidal/Permeability-Increasing Neutrophil Protein on the Bacterial Envelope", J. Immunol., 132(6):3109-3115 (Jun. 1984).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Anti-gram-positive bacterial methods and materials does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Anti-gram-positive bacterial methods and materials, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Anti-gram-positive bacterial methods and materials will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1647213

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.