Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Monoclonal antibody or fragment thereof
Patent
1995-06-07
1998-05-05
Feisee, Lila
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Monoclonal antibody or fragment thereof
4241301, 4241411, 4241431, 4241441, 4241531, 4241731, 435 7011, 4351722, 435326, 435332, 435334, 435343, 4353431, 4353432, 435346, 5303871, 5303881, 5303882, 53038822, 5303887, 53038873, 53038875, A01K 39395, C07K 1628, C12N 512
Patent
active
057470375
ABSTRACT:
Antibodies that bind a protein gp39 (also referred to as CD40 ligand) are disclosed. Preferably, the antibodies are monoclonal antibodies of an IgG1 isotype and bind human gp39. In a preferred embodiment, an antibody of the invention binds an epitope recognized by a monoclonal antibody 24-31, produced by a hybridoma 24-31 (ATTC Accession No. HB11712) or binds an epitope recognized by a monoclonal antibody 89-76, produced by a hybridoma 89-76 (ATCC Accession No.HB11713). Pharmaceutical compositions comprising the antibodies of the invention are also disclosed. The antibodies of the invention are useful for inhibiting B cell proliferation and differentiation, T cell responses and for inducing T cell tolerance. Nucleic acid molecules encoding anti-gp39 antibodies, or portions thereof, as well as expression vectors and host cells incorporating said nucleic acid molecules, are also encompassed by the invention.
REFERENCES:
patent: 5474771 (1995-12-01), Lederman et al.
I. Paul (H2) Fumdamental Immunology 3rd Ed Raveu Press NY p. 242 only.
Foy, T.M. et al. (1993) "In Vivo CD40-gp39 Interactions are essential for Thymus-dependent Hummoral Immunity. II. Prolonged suppression of the Humoral Immune Response by an antibody to the ligand to CD40, gp39" J. Exp Med. 178:1567-1575.
Lederman, S. et al. (1992) "Identification of a novel surface protein on activated CD4.sup.+ T Cells that induces contact-department B cell differentiation (Help)" J. Exp. Med. 175:1091-1101.
Lederman, S. et al. (1992) "Molecular Interactions Mediating T-B Lymphocyte Collaboration in Human Lymphoid Follicles" J. Immnology 149(12):3817-3826.
Marshall, L.S. et al. (1993) "The Molecular Basis for T Cell Help in Humoral Immunity: CD 40 and Its Ligand, gp39" J. Clin. Immunol. 13(3):165-174.
Noelle, R. and E.C. Snow (1992) "T helper cells" Current Opinion in Immunology 4:333-337.
Noelle, R.J. et al. (1992) "A 39-kDa protein on activated helper T cells binds CD40 and transduces the signal for cognate activation of B cells" Proc Natl. Acad. Sci. USA 89:6550-6554.
Noelle, R.J. et al. (1992) "CD40 and its ligand, an essential-ligand-receptor pair for thymus-dependent B-cell activation" Immunology Today 13:431-433.
Aruffo Alejandro
Foy Teresa M.
Ledbetter Jeffrey A.
Noelle Randolph J.
Bristol--Myers Squibb Company
Feisee Lila
Gambel Phillip
Trustees of Dartmouth College
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