Anti-GP39 antibodies

Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Monoclonal antibody or fragment thereof

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4241301, 4241411, 4241431, 4241441, 4241531, 4241731, 435 7011, 4351722, 435326, 435332, 435334, 435343, 4353431, 4353432, 435346, 5303871, 5303881, 5303882, 53038822, 5303887, 53038873, 53038875, A01K 39395, C07K 1628, C12N 512

Patent

active

057470375

ABSTRACT:
Antibodies that bind a protein gp39 (also referred to as CD40 ligand) are disclosed. Preferably, the antibodies are monoclonal antibodies of an IgG1 isotype and bind human gp39. In a preferred embodiment, an antibody of the invention binds an epitope recognized by a monoclonal antibody 24-31, produced by a hybridoma 24-31 (ATTC Accession No. HB11712) or binds an epitope recognized by a monoclonal antibody 89-76, produced by a hybridoma 89-76 (ATCC Accession No.HB11713). Pharmaceutical compositions comprising the antibodies of the invention are also disclosed. The antibodies of the invention are useful for inhibiting B cell proliferation and differentiation, T cell responses and for inducing T cell tolerance. Nucleic acid molecules encoding anti-gp39 antibodies, or portions thereof, as well as expression vectors and host cells incorporating said nucleic acid molecules, are also encompassed by the invention.

REFERENCES:
patent: 5474771 (1995-12-01), Lederman et al.
I. Paul (H2) Fumdamental Immunology 3rd Ed Raveu Press NY p. 242 only.
Foy, T.M. et al. (1993) "In Vivo CD40-gp39 Interactions are essential for Thymus-dependent Hummoral Immunity. II. Prolonged suppression of the Humoral Immune Response by an antibody to the ligand to CD40, gp39" J. Exp Med. 178:1567-1575.
Lederman, S. et al. (1992) "Identification of a novel surface protein on activated CD4.sup.+ T Cells that induces contact-department B cell differentiation (Help)" J. Exp. Med. 175:1091-1101.
Lederman, S. et al. (1992) "Molecular Interactions Mediating T-B Lymphocyte Collaboration in Human Lymphoid Follicles" J. Immnology 149(12):3817-3826.
Marshall, L.S. et al. (1993) "The Molecular Basis for T Cell Help in Humoral Immunity: CD 40 and Its Ligand, gp39" J. Clin. Immunol. 13(3):165-174.
Noelle, R. and E.C. Snow (1992) "T helper cells" Current Opinion in Immunology 4:333-337.
Noelle, R.J. et al. (1992) "A 39-kDa protein on activated helper T cells binds CD40 and transduces the signal for cognate activation of B cells" Proc Natl. Acad. Sci. USA 89:6550-6554.
Noelle, R.J. et al. (1992) "CD40 and its ligand, an essential-ligand-receptor pair for thymus-dependent B-cell activation" Immunology Today 13:431-433.

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