Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Reexamination Certificate
2004-06-17
2008-10-21
Saunders, David A (Department: 1644)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
C530S389100, C530S391300, C435S007900
Reexamination Certificate
active
07439330
ABSTRACT:
The invention includes antibodies or antigen-binding fragments thereof which bind specifically to glycated CD59, compositions containing one or a combination of such antibodies or antigen-binding fragments thereof, hybridoma cell lines that produce the antibodies, and methods of producing and using the antibodies or antigen-binding fragments thereof for diagnosis and treatment of diabetic conditions and diabetic-associated conditions.
REFERENCES:
patent: 4281061 (1981-07-01), Zuk et al.
patent: 4816567 (1989-03-01), Cabilly et al.
patent: 5225539 (1993-07-01), Winter
patent: 5470759 (1995-11-01), Sugiyama et al.
patent: 5585089 (1996-12-01), Queen et al.
patent: 5693762 (1997-12-01), Queen et al.
patent: 5789208 (1998-08-01), Sharon
patent: 5853703 (1998-12-01), Cerami et al.
patent: 5859205 (1999-01-01), Adair et al.
patent: 6835545 (2004-12-01), Halperin
patent: 7049082 (2006-05-01), Halperin
patent: 2004/0219606 (2004-11-01), Halperin
patent: 2006/0257936 (2006-11-01), Halperin
patent: 0394035 (1990-10-01), None
patent: 1789449 (2007-05-01), None
patent: WO 98/19711 (1998-05-01), None
patent: WO 04/106941 (2004-12-01), None
patent: WO 2006/009533 (2006-01-01), None
patent: WO 2006/086098 (2006-08-01), None
Suzuki, D et al. Journal of Diabetes and Its Complications [1996] 10(6):314-319.
Takata, I. et al. Biochem. Biophys. Res. Comm. [1996] 219:243-248.
Harlow et al. Antibodies: A Laboratory Manual. [1988] pp. 321-323.
Acosta, et al.,Proc Natl Acad Sci97, 5450-5455 (2000).
Acosta, et al., Complement and complement regulatory proteins as potential molecular targets for vascular diseases.Current Pharmaceutical Design, 10, 1-9, 2004.
Benzaquen, et al.,J. Exp. Med.179, 985-992 (1994).
Bodian, et al., Mutational analysis of the active site and antibody epitopes of the complement-inhibitory glycoprotein, CD59.J. Exp. Med, 185(3): 507-516, 1997.
Davies, et al.,J. Exp. Med,. 170(3), 637-654 (1989).
Fletcher, et al.,Structure, 2, 185-199 (1994).
Halperin, et al.,J. Clin. Invest., 91, 1974-1978 (1993).
Halperin, et al.,J. Clin. Invest., 80, 128-137 (1987).
Halperin, et al,Blood81, 200-205 (1993).
Hughes, et al.,Biochem. J., 284, 169-176 (1992).
Lapolla, et al., The role of mass spectrometry in the study of non-enzymatic protein glycation in diabetes.Mass Spectrometry Reviews, 19: 279-304, 2000.
Myint, et al.,Biochim. Biophys. Acta1272, 73-79 (1995).
Philbrick, et al.,Eur. J. Immunol., 20, 87-92 (1990).
Rosoklija, et al.,Acta Neuro, 99, 55-62 (2000).
Van Den Berg, et al.,Immunology78, 349-357 (1993).
Zhao, et al.,J. Biol. Chem.266, 13418-13422 (1991).
Zhang, J. et al., Early Complement Activation and Decreased Levels Of Glycosylphosphatidylinositol-Anchored Complement Inhibitors in Human and Experimental Diabetic Retinopathy. Diabetes, 51: 3499-3504, 2002.
Qin, X. et al., A Role of Glycated Human Cd59 and the Complement System in the Pathogenesis of Chronic Vascular Complications of Diabetes. International Immunopharmacology, 2: 1382-1383, 2002.
Qin X. et al., Genomic Structure, Functional Comparison, and Tissue Distribution Of Mouse Cd59a and Cd59b. Mammalian Genome, 12: 582-589, 2001.
PCT/US2006/000310, International Search Report, Oct. 30, 2006.
PCT/US2006/000310, International Preliminary Report on Patentability, Jul. 10, 2007.
PCT/US2004/019392, International Search Report, Jun. 6, 2005.
PCT/US2004/019392, International Preliminary Report on Patentability, Dec. 20, 2006.
President and Fellows of Harvard College
Saunders David A
VanderVegt F. Pierre
Wolf Greenfield & Sacks P.C.
LandOfFree
Anti-glycated CD59 antibodies and uses thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Anti-glycated CD59 antibodies and uses thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Anti-glycated CD59 antibodies and uses thereof will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4011326