Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Animal cell – per se – expressing immunoglobulin – antibody – or...
Patent
1994-12-09
1998-10-06
Feisee, Lila
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
Animal cell, per se, expressing immunoglobulin, antibody, or...
435330, 4241301, 4241371, 4241381, 4241411, 5303871, 5303875, 5303877, 5303881, C12N 512, A61K 39395, C07K 1630
Patent
active
058175130
ABSTRACT:
The present invention relates to immunotherapy strategies for the treatment of malignancies. The present immunotherapy strategies have gangliosides as a target. Gangliosides are glycosphingolipids which are present on normal cells and on malignant cells. On malignant cells they are more abundant and expressed in a different organization and conformation. The present invention provides antibodies which recognize these gangliosides, which antibodies are specific, have recurrent idiotypes and have value as immunoregulators. The invention further provides anti-idiotypic antibodies against anti-ganglioside antibodies. These are useful in vaccination strategies.
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Abraham Amparo E. Macias
Fernandez Angel Mauro Alfonso
Lopez Ana Maria Vazguez
Rodriguez Rolando Perez
Ruiz Maria Eliana Lanio
Centro de Inmunologia Molecular
Feisee Lila
Ungar Susan
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