Anti-ganglioside GD.sub.1 A monoclonal antibody MZ, MZ-producing

Details Anti-ganglioside GD.sub.1 A monoclonal antibody MZ, MZ-producing Anti-ganglioside GD.sub.1 A monoclonal antibody MZ, MZ-producing

1988-09-07

1993-03-09

Kepplinger, Esther L.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 72, 435 721, 4351722, 43524027, 436813, 436 64, 436548, 5303888, 53038885, G01N 33574, G01N 33532, C07K 1528

Patent

active

051926628

ABSTRACT:
Disclosed is a novel anti-ganglioside GD.sub.1a monoclonal antibody (MZ) which is capable of recognizing ganglioside GD.sub.1a but is practically incapable of recognizing GalCer, LacCer, Gb.sub.3, Gb.sub.4, GA.sub.1, GA.sub.2, GM.sub.2, GM.sub.3, GD.sub.1b, GT.sub.1b, GQ.sub.1b, Fuc-GM.sub.1, nLc.sub.4 and sialosyl nLc.sub.4 ; MZ-producing cells; an MZ-containing reagent; and a method for the detection or quantification of GD.sub.1a using the reagent, e.g., to diagnose cancer, systematic lupus erythematosus and diseases resulting from organic injury of the nervous system.

REFERENCES:
J. Cell Biol. Suppl., vol. 0, No. 11, Part D, No. R312, p. 161 (1987).
Endo et al. J. Immunol. 132(4):1324, 1984.
H.ang.kansson et al. J. Biochem. 98:843, 1985.
Hakomori et al. JNCI 71(27:231, 1983.
Kohler et al. Nature 256:495, 1975.

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