Anti-fungal histatin-based peptides

Details Anti-fungal histatin-based peptides Anti-fungal histatin-based peptides

1994-08-09

1996-01-23

Wax, Robert A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530324, 530325, 530326, 530327, 435691, 4352523, 4353201, 935 10, 935 72, A61K 3810, A61K 3816, C07K 704, C07K 1400

Patent

active

054865034

ABSTRACT:
Peptides representing defined portions of the amino acid sequences of naturally occurring human and macaque histatins, modified peptides, expression vectors encoding these peptides, and compositions and methods for treatment of fungal infection are described. Some of the histatin-based peptides exhibit superior anti-fungal activity to native, intact histatins. Isolated, naturally occurring macaque histatins and peptide analogs are also described.

REFERENCES:
patent: 4705777 (1982-11-01), Lebrer et al.
patent: 4725576 (1988-02-01), Pollock et al.
patent: 5032574 (1991-07-01), Wilde et al.
patent: 5126257 (1992-06-01), Gabay et al.
patent: 5221732 (1993-06-01), Chen et al.
patent: 5225399 (1993-07-01), Zasloff et al.
patent: 5239059 (1993-08-01), Zasloff et al.
patent: 5304633 (1994-04-01), Tomita et al.
patent: 5324716 (1984-06-01), Solsted et al.
Minaguchi, K., et al., 1989, Journal of Dental Research, 68(1):2-15.
VanderSpek, J. C., et al., 1989, American Journal of Human Genetics, 45:381-387.
Santarpio, R. P., et al., 1988, Archives of Oral Biology 33(8): 567-573.
Dickinson, D. P., et al., 1987, Biochemical and Biophysical Research Communications, 149(2): 784-790.
Sugiyama, K., et al., 1990, Archives of Oral Biology, 35(6):415-419.
Sabatini, L. M., et al., 1989, Journal of Dental Research, 68(7):1138-1145.
Vander Spek, J. C. et al., 1990, Archives of Oral Biology 35(2): 137-143.
Raj, P. A., et al., 1990, The Journal of Biological Chemistry, 265(7):3898-3905.
Murakomi, Y., et al., 1990, Archives of Oral Biology 35(9):775-777.
Sabatini, L. M., et al., 1989, Biochemical and Biophysical Research Communications, 160(2):495-502.
Sabatini, L. M., et al., 1988, American Journal of Human Genetics, 43 (3, Supplement): A199, Abstract 0795.
Docherty, J. J. and Pollock, J. J., "Inactivation of herpes simplex virus types 1 and 2 by synthetic histidine peptides", (Oct. 1987).
Nishikata, M. et al., "Salivary histatin as an inhibitor of a protease produced by the oral bacterium Bacteroides gingivalis", Biochem. Biophys. Res. Comm., 174(2):625-630 (Jan. 1991).
Xu, T. et al., "Primary structure and anti-candidal activity of the major histatin from parotid secretion of the subhuman primate, Macaca fascicularis", J. Dent. Res. 69:1717-1723 (1990).
Xu, T. and Oppenheim, F. G., "Anti-fungal functional domain of histatin 3", J. Dent. Res. 7:497 (Apr. 1991).
Xu, T. et al., "Anticandidal activity of major human salivary histatins", Infect. Immun., 59(8):2549-2554 (Aug. 1991).
Troxler, R. F. et al., "Structural relationship between human salivary histatins", J. Dent. Res., 69(1):2-6 (Jan. 1990).
Santarpia III, R. P. et al., "Preliminary findings for in vivo efficacy of salivary histidine-rich polypeptides", J. Dent. Res., 69:173 (Mar. 1990).
Iwaki, M. et al., "Oral immunization with recombinant Streptococcus lactis carrying the Streptococcus mutans surface protein antigen gene", Infect. Immun. 58(9):2929-2934 (Sep. 1990).
Macrina, F. L. et al., "Chimeric streptococcal plasmids and their use as molecular cloning vehicles in Streptococcus sanguis (Challis)", J. Bacteriol., 143(3):1425-1435 (Sep. 1980).
Kuramitsu, H. K. and Long, C. M., "Plasmid-mediated transformation of Streptococcus mutans", Infect. Immun., 36(1):435-6 (Apr. 1982).
Svanberg, M. et al., "Oral implantation in humans of Streptococcus mutans strains with different degrees of hydrophobicity", Infect. Immun. 43(3):817-821 (Mar. 1984).
Oppenheim, F. G. et al., "Isolation and characterization of a major histatin from macaque parotid secretion", FASEB J, 4(7): A2165 (Apr. 1990).
Xu, T. and Oppenheim, F. G., "Structure/function analysis of anti-Candida activities of histatin 1", J. Dent. Res., 68:973 (Jun. 1989).
Oppenheim, F. G. et al., "Histatins, a novel family of histidine-rich proteins in human parotid secretion", J. Biol. Chem., 263(16):742-77 (Jun. 1988).

Affiliated with

Also associated with

Rating

Anti-fungal histatin-based peptides does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Anti-fungal histatin-based peptides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Anti-fungal histatin-based peptides will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1505046