Anti-fungal and anti-bacterial histatin-based peptides

Details Anti-fungal and anti-bacterial histatin-based peptides Anti-fungal and anti-bacterial histatin-based peptides

1995-06-07

1997-05-20

Wax, Robert A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 12, 514 13, 514 14, 514 15, 530324, 530325, 530326, 530327, 435 641, 4352573, 4353201, A61K 3808, A61K 3810, C07K 706, C07K 708

Patent

active

056312288

ABSTRACT:
Histatin-based peptides representing defined portions of the amino acid sequences of naturally occurring human histatins and methods for treatment of fungal or bacterial infection are described. These histatin-based peptides represent the active anti-fungal and anti-bacterial region of naturally occurring human histatins.

REFERENCES:
patent: 4725576 (1988-02-01), Pollock et al.
patent: 5032574 (1991-07-01), Wilde et al.
patent: 5221732 (1993-06-01), Chen et al.
patent: 5225399 (1993-07-01), Zasloff et al.
patent: 5239059 (1993-08-01), Zasloff et al.
patent: 5304633 (1994-04-01), Tomita et al.
patent: 5324716 (1994-06-01), Selsted et al.
patent: 5486503 (1996-01-01), Oppenheim et al.
Edgerton, M., et al., Journal of Biomedical Material Research, vol. 29, "Surface-modified poly(methyl methacrylate) enhances adsorption and retains anticandidal activities of salivary histatin 5", pp. 1277-1286, 1995.
Zuo, Y., et al., Gene, vol. 161, "Recombinant histatins: functional domain duplication enhances candidacidal activity", pp. 87-91, 1995.
Murakami, Y. et. al., "Inhibitory Effects of Synthetic Histidine-Rich Peptides on Haemagglutination by Bacteroides Gingivalis 381", Arch. Oral Biol., 35(9): 775-777 (1990).
Oppenheim, F.G. et. al., "Histatins, a Novel Family of Histidine-Rich Proteins in Human Paretoid Secretion", J. Biol. Chem., 263(16):7472-7477 (Jun. 1988).
Xu, T. et. al., "Anticandidal Activity of Major Human Salivary Histatins", Infect. Immunol., 59(8):2549-2554 (Aug. 1991).
Xu, T. et al., "Anti-fungal Functional Domain of Histatin 3", J. Dent. Res. 70:497 (Apr. 1991) (Abstract No. 1852).
Raj, P.A. et al., "Salivary Histatin 5: Depnedence of Sequence, Chain Length, and Helical Confirmation for Candidacidal Activity", J. Biol. Chem., 265(7):3898-3905 (Mar. 15, 1990).
Santarpia III, R.P. et. al., "A Comparison of the Inhibition of Blastospore Viability and Germ-Tube Development in Candida albicans by Histidine Peptides and Ketoconazole", Arch. Oral Biol., 33(8):567-573 (1988).
Santarpia III, R.P. et. al., "Preliminary Findings for In Vivo Efficacy of Salivary Histidine-Rich Polypeptides", J. Dent. Res., 69:173 (Mar. 1990).
Troxler, R.F. et. al., "Structural Relationship Between Human Salivary Histatins", J. Dent. Res., 69(1):2-6 (Jan. 1990).
Xu, T. et al., "Primary Structure and Anticandidal Activity of the Major Histatin from Parotid Secretion of the Subhuman Primate, Macac fascicularis," J. Dent. Res., 69(11):1717-1723 (Nov. 1990).
Xu, T. et al., "Structure/Function Analysis of Anti-Candida Activities of Histatin 1," J. Dent. Res., 68:973 (Jun. 1989).
Nishikata, M. et al., "Salivary Histatin as an Inhibitor of a Protease Produced by the Oral Bacterium Bacteroides gingivalis," Biochem. Biophys. Res. Comm., 174(2):625-630 (Jan. 31, 1991).

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