Anti-fungal agents and methods of identifying and using the same

Details Anti-fungal agents and methods of identifying and using the same Anti-fungal agents and methods of identifying and using the same

1995-06-07

1997-11-25

Wax, Robert A.

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Bacteria or actinomycetales; media therefor

4353201, 43525411, 435325, 435410, 43525233, 43525421, 536232, C12N 1561, C12N 1563, C12N 114, C12N 116, C12N 118, C12N 510, C12N 121

Patent

active

056911874

ABSTRACT:
Substantially pure C. albicans topoisomerase I protein is disclosed. Nucleic acid molecules that encode C. albicans topoisomerase I protein, recombinant expression vectors that comprise a nucleic acid sequence that encodes C. albicans topoisomerase I protein, and host cells that comprise recombinant expression vectors that comprise nucleic acid sequences that encode C. albicans topoisomerase I protein are disclosed. Fragments of nucleic acid molecules with sequences encoding C. albicans topoisomerase I protein and oligonucleotide molecules that comprise a nucleotide sequence complimentary to fragment of a nucleotide sequence that encodes C. albicans topoisomerase I protein are disclosed. Antibodies which bind to an epitope on C. albicans topoisomerase I protein are disclosed. Methods of identifying inhibitors of C. albicans topoisomerase I protein are disclosed.

REFERENCES:
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patent: 4873191 (1989-10-01), Wagner et al.
Fostel et al. "Characterization of DNA Topoisomerase I from Candida albicans as a target for drug discovery". Antimicrobial Agents and Chemotherapy 36(10):2131-2138, Oct. 1992.
Shen et al., "DNA topoisomerase inhibitors as antifungal agents." Advances in Pharmacology 29B:227-244, 1994.
Taylor, et al., "Identification of the gene encoding DNA topoisomerase I from Candida albicans", FEMS Microbiology Letters, 1996, 138, 113-121.
Bjournsti, et al., "Expression of Human DNA Topoisomerase I in Yeast Cells Lacking Yeast DNA Topoisomerase I: Restoration of Sensitivity of the Cells to the Antitumor Drug Camptothecin.sup.1 ", Cancer Research, 49, 6318-6323 (1989).
Elble, R., "A Simple and Efficient Procedure for Transformation of Yeasts", Biotechniques, 13(1), 18-20 (1992).
Thrash, et al., "Cloning, characterization, and sequence of the yeast DNA topoisomerase I gene", Proc. Natl. Acad. Sci. USA, 82, 4374-4378 (1985).

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