Drug – bio-affecting and body treating compositions – Effervescent or pressurized fluid containing – Organic pressurized fluid
Patent
1993-01-26
1994-10-04
Page, Thurman K.
Drug, bio-affecting and body treating compositions
Effervescent or pressurized fluid containing
Organic pressurized fluid
424 941, 424 944, 424401, 514836, 514844, A61K 3748, A61K 700
Patent
active
053524381
DESCRIPTION:
BRIEF SUMMARY
The present invention has as its goal cosmetic or pharmaceutical compositions containing a dismutase superoxide (DSO) in combination with derivatives of phosphonic acid used as a metal chelating agent.
These compositions are applied topically, in particular in the fight against skin aging and in protecting skin against radiation exposure.
It is known that dismutase superoxides are enzymes capable of inducing the dismutation of superoxide ions, in accordance with the reaction: ##STR1##
Dismutase superoxides extracted from cow erythrocytes (Markovitz, J. BIOL. CHEM., 234, p. 40, 1959) and from Escherichia coli (Keele and Fridovich, J. BIOL. CHEM., 245, p. 6176, 1970) have been previously described.
Both dismutase superoxides extracted from marine bacterial strains and the procedure used for their preparation are described in French Patent Application No. 73,13670, filed on Apr. 16, 1973.
Dismutase superoxides make it possible, in particular, to protect the skin and hair, while preserving intact the natural keratinous structure, as described, for example, in French Patent Application No. 75,31354. The protection thus afforded may be due to the inhibition of keratin-oxidation phenomena. The dismutase superoxides enhance cutaneous cellular respiration and preserve, or improve, skin qualities, i.e., softness to the touch, suppleness, and elasticity. The presence of these superoxides in hair compositions also allows preservation or enhancement of scalp quality, while at the same time protecting the skin on the hands of the person applying these compositions.
Furthermore, dismutase superoxides protect the skin against inflammatory phenomena caused by ultra-violet radiation, and against skin aging resulting from this same stimulus.
By means of these various properties, dismutase superoxides can be used in cosmetic preparations for skin or hair, as well as in pharmaceutical compounds used dermatologically or ophthalmologically.
In fact, the superoxide ion O.sub.2.sup.- (active oxygen) is a free radical whose instability and reactivity in the case of an organism make it a toxic compound, since, in the presence of metal ions, it produces highly-toxic hydroxyl radicals (OH).
The DSO produces a protective effect, by trapping the superoxide ions. It thus forms a biological defense system against the toxic effects of oxygen.
It was revealed that the chelating agents, and thus the metal inactivating agents, may, in some cases, attenuate production of the toxic OH radicals.
It has how been found, in an entirely unexpectedly, surprising way, that not all of the metal chelating agents are suitable, since some of them are, moreover, agents which activate radical reactions, and thus act to oppose the suppression of formation of these free radicals.
Therefore, the present invention has, as its goals, an anti-radical composition characterized by the fact that it comprises the dismutase superoxide in combination with at least one of a special selection of metal chelating agents, especially the derivatives of phosphonic acid, preferably polyphosphonic derivatives, which do not simultaneously stimulate the formation of free radicals. To the contrary, these derivatives reinforce synergistically the protective action exerted by the DSO.
Most especially, the invention has as its aim a cosmetic composition intended for topical use, characterized by the fact that this composition contains at least one dismutase superoxide in combination with at least one phosphonic derivative used as metal chelating agent.
The aforementioned synergistic effect between the DSO and the phosphonic compound is especially pronounced when the weighted ratio of DSO to the phosphonic compound(s) ranges between 2 and 25, and preferably between 10 and 25.
The term "DSO" signifies any constituent producing a dismutase superoxide action, i.e., any enzyme capable of catalyzing the dismutation reaction mentioned previously, as well as any product producing this activity, these products forming a group including, in particular, DSO's modified by grafting with polyalkyl
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Eur. J. Rheumatal and Inflammation, 4, pp. 173-182, 1982, "Orgotein-(Bovine Cu-Zn Superoxide Dismutase), An Anti-Inflammatory Protein Drug: Discovery, Toxicology and Pharmacology", pp. 173-182.
International Conference on Medical, Biochemical and Chemical Aspects of Free Radicals, Apr. 9-13, 1982, Morimoto et al., "Preparation of Polyoxyethylene-Modified Superoxide Dismutase", p. 317.
New Trends in Allergy II, ed. Ring et al., Springe-Verlag, "Superoxide Dismutase: Rationale of Therapeutic Use, Established Clinical Effects, and Perspectives", 1986, pp. 325-534.
International Conference on Medical, Biochemical and Chemical Aspects of Free Radicals, Apr. 9-13, 1988, Ando et al., "Synthesis of SOD Derivatives Which Bind to Biomembrane Surface", p. 318.
Galey Jean-Baptiste
N'Guyen Quang L.
"L'Oreal"
Harrison Robert H.
Page Thurman K.
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