Anti-FR-900506 substance antibodies and highly-sensitive enzyme

Details Anti-FR-900506 substance antibodies and highly-sensitive enzyme Anti-FR-900506 substance antibodies and highly-sensitive enzyme

1996-06-06

1996-07-02

Mosher, Mary E.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 71, 435 79, 435 793, 435 28, 435 7021, 4351722, 43524027, 435810, 436518, 436548, 436808, 5303871, 5303889, 5303914, 530808, 530809, 530815, 530864, 530868, C07K 1600, G01N 3353, G01N 33543

Patent

active

055321372

ABSTRACT:
Monoclonal or polyclonal antibodies capable of recognizing at least one antigenic determinant located on the FR-900506 compound, are disclosed. FR-900506 is
a compound having pharmacological activities such as immunosuppressive activity and antimicrobial activity, and has the following structure: ##STR1## Also disclosed are enzyme immunoassays for FR-900506 based on the antibodies of the invention and test kits for detection of FR-900506. A process for preparing a monoclonal antibody which selectively binds to FR-900506 is also disclosed.

REFERENCES:
Tamura et al. Chem Abstracts, vol. 108, 1988, 48617g, "A Highly Sensitive Method to Assay FK-506 Levels in Plasma".
Oellerich, J. Clin. Chem. Clin. Biochem. vol. 22, 1984, pp. 895-904.
P. J. Marangos et al.: Journal of Neurochemistry vol. 33, pp. 319 to 329 (1979).
G. Kohler, C. Milstein: Nature vol. 256, pp. 495 to 497 (1975).
Tamura et al., Trans. Proc., vol. XIX, No. 5, Suppl 6 pp. 23-29 (1987).
U.S. Ser. No. 08/465,934 filed Jun. 6, 1995 pending.
U.S. Ser. No. 08/379,563 filed Feb. 10, 1995 pending.

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