Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1992-05-27
1994-07-19
Hutzell, Paula
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
5303881, 5303888, 435 723, 43524027, C07K 1528, G01N 33574, C12N 512
Patent
active
053310934
ABSTRACT:
The invention relates to a monoclonal antibody PC47H specifically recognizing fucosylceramide derived from a ceramide-mono-glycoside fraction of neutral glycolipid extracted and purified from human cancer tissues and having properties such as belonging to IgM and showing reactivity to neither of normal peripheral blood lymphocyte, normal erythrocyte, normal fibroblast nor cell lines derived from leukemia, hepatoma, breast cancer and neuroblastoma but to cell lines derived from lung cancer, stomach cancer, colon cancer and pancreas cancer; a hybridoma having ability to produce the aforementioned monoclonal antibody; a method for manufacturing the aforementioned monoclonal antibody which comprises immunizing an animal with a neutral glycolipid fraction extracted from human pancreas cancer, fusing animal cells with myeloma cells to generate hybridomas, cloning the hybridomas, selecting clones which produce monoclonal antibodies which specifically recognize fucosylceramide and then using the clones to manufacture the monoclonal antibody; and a diagnostic aid of cancers such as lung cancer, stomach cancer, colon cancer and pancreas cancer containing the aforementioned monoclonal antibody as an active component.
REFERENCES:
Campbell, A. M., Monoclonal Antibody Technology, Chapters 1 ands 2, pp. 1-65, 1985.
Yoshino, et al., Biochemistry, 21:928-934, 1982.
Hattori Hiroshi
Ishihara Hideki
Ono Ken'ichi
Hoechst Japan Limited
Hutzell Paula
Loring Susan A.
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