Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1997-04-03
1999-09-14
Hutzell, Paula K.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
5303879, 5303881, 5303882, 53038823, 53038885, 5303877, 435326, C07K 1600, C12N 506
Patent
active
059524723
ABSTRACT:
Described is a monoclonal antibody capable of specifically binding to fibroblast growth factor-8 (FGF-8) which is related to growth factors of hormone-dependent tumor cells such as prostatic cancer and breast cancer, and inhibits the FGF-8 activity. The monoclonal antibody is useful in analyzing the role and biological function of FGF-8 in hormone-dependent tumor cells such as prostatic cancer and breast cancer and can be beneficial in the treatment of these cancers.
REFERENCES:
Prac. Natl. Acad. Sci. USA, vol. 89, pp. 8928-8932, Oct. 1992, Biochemistry, "Cloning and characterization of an androgen-induced growth factor essential for the androgen-dependent growth of mouse mammary carcinoma cells", Tanaka et al.
FEBS Letters 3663 (1995) 226-230, Federation of European Biochemical Societies, "Human androgen-induced growth factor in prostate and breast cancer cells: its molecular cloning and growth properties", Tanaka et al.
MacArthur et al. 1995 Cell Growth & Differ Entition vol. 6:817-825.
Essential Immunology Blackwell Scientific Publications Oxford England pp. 107-109.
Furuya Akiko
Hanai Nobuo
Tanaka Akira
Yamasaki Motoo
Hutzell Paula K.
Kyowa Hakko Kogyo Co. Ltd.
Ungar Susan
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