Anti-fertility composition and method

Details Anti-fertility composition and method Anti-fertility composition and method

1976-12-27

1981-02-24

Rose, Shep K.

Drug, bio-affecting and body treating compositions

Effervescent or pressurized fluid containing

Organic pressurized fluid

424242, 424 44, 128260, 128271, 128251, A61K 912, A61K 740, A61K 902, A61K 3157

Patent

active

042527872

ABSTRACT:
A self-administrable anti-fertility composition comprising a progestational compound in an amount effective for alteration of cervical mucus secretions in a manner unfavorable to fertility without systemic absorption and a pharmaceutically acceptable vehicle. A typical composition is a foamable aqueous emulsion containing an anionic surfactant, propylene glycol and an amount of progesterone effective to provide a dose of from about 10 micrograms to about 5 miligrams. The composition may be foamed by dispensing with a syringe or by dispensing from an aerosol container.

REFERENCES:
patent: 2943979 (1960-07-01), Elias
patent: 3170464 (1965-02-01), Forti et al.
patent: 3219525 (1965-11-01), Berkow et al.
patent: 3244589 (1966-04-01), Sunnen et al.
patent: 3262450 (1966-07-01), Elias
patent: 3342181 (1967-09-01), Jacquignon
patent: 3384541 (1968-05-01), Clark
patent: 3443563 (1969-05-01), Ishihama et al.
Ringler Steroids 1(4):341-349, Apr. 1966, "Efficacy of Topically Applied Progestational Agents".
Shipley Steroids 5(5):699-717, May 1965, "Effectiveness of Topical Application of a Number of Progestins".
Kincl et al., Steroids 8(1):5-11 Jul. 1966, "Inhibition of Ovulation in the Adult Estrus Rabbit by Vaginal Deposition".
Greenplatt J. Clin. Endocrin, 14:1564-1567, Dec. 1954, "The Physiological Effectiveness of Progesterine Vaginal Suppositories".

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