Anti-feline calicivirus recombinant antibody and gene fragment e

Details Anti-feline calicivirus recombinant antibody and gene fragment e Anti-feline calicivirus recombinant antibody and gene fragment e

1993-03-01

1998-07-28

Feisee, Lila

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Monoclonal antibody or fragment thereof

5303894, 4241591, 4241331, 536 2353, C07H 2104, C07H 1600, A61K 39395

Patent

active

057859680

ABSTRACT:
Anti-FCV (feline calicivirus) feline-type recombinant antibody effective for treatment, prevention and diagnosis of FCV infection and a gene fragment useful for preparation of said antibody are provided. Cell line 1D7 capable of producing a mouse monoclonal antibody having an excellent FCV-neutralizing activity was constructed and a gene fragment coding for the V region in charge of the FCV-specific binding of said antibody was obtained. This gene fragment and the gene coding for the constant region of the feline antibody are used to give a chimeric anti-FCV recombinant antibody. The obtained recombinant antibody is a novel antibody and is useful for the diagnosis, treatment and prevention of feline virus infections, particularly feline calicivirus infection, with high safety in administration into cats.

REFERENCES:
patent: 3937812 (1976-02-01), Bittle et al.
patent: 3944469 (1976-03-01), Bittle et al.
Man Sung Co et al., "Humanized Antibodies for Antiviral Therapy," Proc. N. Acad. Sci. USA, vol. 88, No. 7, pp. 2869-2873, Apr. 1991.
Vernon T. Oi et al., "Chimeric Antibodies," Biotechniques, vol. 4, No. 3, pp. 214-221 (1986).
Queen et. al. PNAS. 86: 10029 1989.
Tohya et. al. Arch Virol 117 (3-4) 1991 173-182.

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