Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1996-05-17
2000-09-05
Stucker, Jeffrey
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
435326, 4241451, 4241851, C07K 1600, C12N 500, A61K 39395, A61K 3900
Patent
active
061145076
ABSTRACT:
An anti-Fas ligand antibody capable of suppressing Fas ligand-induced apoptosis to a high degree, especially humanized antibodies having less antigenecity to human, and a method for assaying the Fas ligand in human body fluid utilizing such an antibody.
Measurement of the Fas ligand in human body fluid would be useful for elucidation of hepatitis B, hepatitis C, HIV infections and the like, and for prediction and diagnosis of pathological conditions associated with such diseases.
REFERENCES:
Tanaka et al. (1995) The EMBO Journal vol. 14, No. 6, pp. 1129-1135.
Man Sung Co. et al. (1991) Proc. Natl. Acad. Aci, USA, vol. 88, pp. 2869-2873.
Riechmann et al. (1988) Nature, vol. 332, pp.323-327.
Man Sung Co. et al. (1992) The Journal of Immunology, vol.148, 1149-1154, No. 4.
Tanaka et al. (1996) Nature Medicine, vol. 2, No. 3, pp.317-322.
Queen et al. (1989) Proc. Natl. Acad. Sci, USA, vol. 86, pp. 10029-10033.
Man Sung Co., et al. (1994) The American Assoc. of Immunologiest, pp. 2968-2976.
Kayagaki et al, J. Exp. Med., vol. 182, No. 6, pp. 1777-1783 (Dec. 1995).
Yonehara et al., A cell-killing monoclonal antibody (Anti-Fas) to a cell surface antigen co-downregulated with the receptor of tumor necrosis factor, J. Exp. Med., 169, 1747-1756, May 1989.
Takahashi et al., Human Fas ligand: gene structure, chromosomal location and species specificity, Int. Immunol., 6(10), 1567-1574, Jun. 1994.
Mariani et al., Eur. J. Immunol. 25:2303-2307 (1995).
Co Man Sung
Matsusue Tomokazu
Nagata Shigekazu
Shirakawa Kamon
Vasquez Maximiliano
Mochida Pharmaceutical Co. Ltd.
Osaka Bioscience Institute
Park Hankyel T.
Stucker Jeffrey
LandOfFree
Anti-Fas ligand antibody and assay method using the anti-Fas lig does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Anti-Fas ligand antibody and assay method using the anti-Fas lig, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Anti-Fas ligand antibody and assay method using the anti-Fas lig will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2213402