Anti-erbB-2 antibodies, combinations thereof, and therapeutic an

Details Anti-erbB-2 antibodies, combinations thereof, and therapeutic an Anti-erbB-2 antibodies, combinations thereof, and therapeutic an

1993-05-14

1996-12-24

Adams, Donald E.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

5303877, 53038822, 5303897, 5303913, 5303917, 436501, 436512, C07K 1600, C07K 1646, C07K 1628

Patent

active

055874584

ABSTRACT:
The present invention relates to novel antibodies, in particular monoclonal and single chain antibodies derived therefrom which specifically bind to erbB-2, as well as diagnostic and therapeutic uses thereof. The present invention also relates to a combination of at least two erbB-2 specific antibodies which are capable of preventing and treating human malignancies wherein the malignant cells overexpress gp185.sup.erbB-2. The monoclonal antibodies of the combination preferably recognize different epitopes of the gp185 expression product of erbB-2, therefore, the antibodies do not cross react with each other. Preferably, the combination will provide for synergistic decrease in the expression of the erbB-2 gene product.

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