Anti-emetic quinuclidinyl benzamides

Details Anti-emetic quinuclidinyl benzamides Anti-emetic quinuclidinyl benzamides

1987-05-18

1989-04-11

Schwartz, Richard A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546133, A61K 31445, C07D45302

Patent

active

048207152

ABSTRACT:
Novel substituted benzamides of the formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and A are as defined herein are useful in the treatment of emesis, and particularly chemotherapy-induced emesis in cancer patients. Some of the compounds are also useful in disorders relating to impaired gastric motility.

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Derwent Abstract of Japan 52 097,968, 8/17/77.

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