Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Food or edible as carrier for pharmaceutical
Patent
1995-01-23
1996-04-09
Page, Thurman K.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Food or edible as carrier for pharmaceutical
424440, 424441, 424484, 514867, A61K 4500, A61K 968
Patent
active
055059554
ABSTRACT:
An anti-diarrheic product comprises a foodstuff and an anti-rotaviral agent such as human defatted fat globule membranes, the human milk macromolecular fraction, the milk mucin complex, the 46 Kd apparent MW glycoprotein, a polypeptide having the rotavirus-binding specificity of the 46 Kd apparent MW HMFG glycoprotein, mixtures thereof, or mixtures thereof, and optionally skim milk, curd, and/or whey. They product of the invention is provided also as an anti-diarrheal kit, with instructions for its use. The product of the invention has therapeutic and prophylactic application for inhibiting the onset of, or countering, rotavirus infection and/or diarrhea, in a subject, such as for example, infants and children (infantile gasteroenteritis), travellers, and immunodeficient persons, including HIV positive and transplant patients.
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Larocca, D. D., et al., "Cloning and Sequencing of a Complementary DNA Encoding a M.sub.r 70,000 Human Breast Epithelial Mucin-associated Antigen", Cancer Research 50:5925-5930 (1990).
Larocca, D. D., et al., "A M.sub.r 46,000 Human Milk Fat Globule Protein That Is Hughly Expressed in Human Breast Tumors Contains Factos VIII-like Domains", Cancer Research 51:4994-4998 (1991).
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Newburg David S.
Peterson Jerry A.
Yolken Robert H.
Bawa Raj
Cancer Research Fund of Contra Costa
Page Thurman K.
Senomed, Inc.
The Johns Hopkins Univ. School of Medicine
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