Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal
Patent
1975-04-16
1976-12-21
Jiles, Henry R.
Chemistry of carbon compounds
Miscellaneous organic carbon compounds
C-metal
260239B, 26029371, 260283R, 26029373, 26029381, 26029384, 260296D, 260296T, 26032687, 424263, 424267, 424274, C07D40102
Patent
active
039988325
ABSTRACT:
The present invention comprehends a method for treating diarrhea comprising administering to an animal in need of anti-diarrheal treatment an effective antidiarrheal amount of a compound of the formula ##STR1## AND ACID ADDITION SALTS THEREOF WHEREIN Y is alkylene containing 1-4 carbon atoms; R.sub.2 and R.sub.3 together with N is a heterocyclic ring system comprising azamonocyclic ring of the formula ##STR2## wherein Z is phenylhydroxymethylmethylene, phenylhydroxymethylene, phenylcarboxymethylene, phenylcarbalkoxymethylene or azabicycloalkyl or phenyl or hydroxyl substituted azabicycloalkyl containing 6-9 carbon atoms and containing at least 5 atoms in each ring of the azabicycloalkyl or 4-azatricyclo[4.3.1.1.sup.3,8 ]undec-4-yl; Ar.sub.1 and Ar.sub.2 are phenyl, halo-substituted phenyl, (lower alkyl) substituted phenyl, pyridyl, thienyl or furyl, and Ar.sub.3 is phenyl, halo-substituted phenyl, (lower alkyl) substituted phenyl, pyridyl, thienyl, furyl, pyrrolyl, imidazoyl, oxazolinyl, oxazolinyl, thiazolinyl, thiazolyl, 1,2,4-oxodiazolyl, and isoxazolinyl. The present invention also comprehends novel compounds included in the above formula.
REFERENCES:
patent: 2604473 (1952-07-01), Sperber et al.
patent: 3917615 (1975-11-01), Adelstein
Patai, et al., J.C.S. 716 (1962).
Martensson, et al., Acta Chem. Scand. 19 (3) 711 (1965).
Adelstein Gilbert W.
Dajani Esam Z.
Yen Chung Hwai
G. D. Searle & Co.
Jaisle C. M. S.
Jiles Henry R.
McDonnell John J.
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