Anti-diabetic pharmaceutical compositions and the preparation th

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514866, A61K 3179

Patent

active

048637246

ABSTRACT:
Galenic compositions containing an oral antidiabetic agent and having an improved release of active substance are provided, as well as processes for producing these compositions. The compositions are characterized in that the onset of the activity and the duration of activity are adapted to the particular needs of diabetics with regard to proper control of the metabolism and the associated proper release of insulin. A basic or acidic excipient in a solvent is added to the antidiabetic active substance in a quantity such that the active substance is made soluble, and then a solubilizing agent is added. Polyvinylpyrrolidone is dissolved as carrier in this solution, but the carrier may simultaneously serve as the solubilizing adjuvant. This solution is further processed with other excipients to form pharmaceutical compositions.

REFERENCES:
patent: 3708481 (1973-01-01), Kufter
patent: 4696815 (1987-09-01), Schepky

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