Anti-diabetic compounds

Details Anti-diabetic compounds Anti-diabetic compounds

1984-06-14

1986-04-08

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07C10352

Patent

active

045811652

ABSTRACT:
A class of compounds having insulin-like activity is described. These compounds have the formula ##STR1## in which X is --OH, -Arg-Arg-OH, or -Arg-Arg-Glu-Ala-Glu-Asp-Leu-Gln-Val-Gly-Gln-Val-Glu-Leu-Gly-Gly-Gly-Pro-G ly-Ala-Gly-Ser-Leu-Gln-Pro-Leu-OH.

REFERENCES:
Geiger et al., Chem. Ber., 106, 2339-2352 (1973).
Chemical Abstracts, 82, 49 (1975), Abst. No. 68464c.
Steiner et al., Diabetes 17, 725-736 (1968).
Chance, Proceedings of the VII Congress of the International Diabetes Federation, Buenos Aires, 1970, Excerpta Medica International Congress Series No. 231, pp. 292-305.
Kemmler et al., J. Biol. Chem. 246, 6787-6791 (1971).
Gutman et al., Diabetologia 8, 136-140 (1972).
Chance, Diabetes 21, 461-467 (1972).
Yu et al., J. Biol. Chem. 248, 3753-3761 (1973).
Gavin et al., J. Clin. Endocrinol. Metab. 41, 438-445 (1975).
de Haen et al., J. Clin. Invest. 62, 727-737 (1978).

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