Anti-depressant imidazoles, compositions and use

Details Anti-depressant imidazoles, compositions and use Anti-depressant imidazoles, compositions and use

1985-06-06

1986-07-22

Ramsuer, Robert W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548346, A61K 31415, C07D23161

Patent

active

046020314

ABSTRACT:
An antidepressive imidazole compound of the formula: ##STR1## wherein R.sub.1 is lower alkyl, R.sub.2 is hydrogen or lower alkyl, and R.sub.3, R.sub.4 and R.sub.5 are hydrogen, lower alkyl, trifluoromethyl, amino, mono- or di-lower alkylamino, heterocyclic amino, halogen or ##STR2## (in which R.sub.6 is hydrogen, lower alkyl or lower alkylsulfonyl, A is carbonyl or sulfonyl, and R.sub.7 is lower alkyl, halogenated lower alkyl, mono- or di-lower alkylamino, mono- or di-lower alkylaminoalkyl, unsubstituted phenyl or phenyl having halogen, lower alkyl, lower alkoxy or trifluoromethyl, phenylamino or phenylamino having halogen, lower alkyl, lower alkoxy or trifluoromethyl); and their pharmaceutically acceptable acid addition salts.

REFERENCES:
patent: 4172947 (1979-10-01), Warner et al.
patent: 4301169 (1981-11-01), Yamanaka et al.
patent: 4402966 (1983-09-01), Yamanaka et al.

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