Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1983-02-25
1985-08-06
Schwartz, Richard A.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514399, 548236, 548342, 548346, A61K 31415, C07D23361, C07D23356
Patent
active
045336695
ABSTRACT:
An anti-depressant imidazole compound of the formula: ##STR1## wherein R.sub.1 is lower alkyl, R.sub.2 is hydrogen or lower alkyl, and R.sub.3, R.sub.4 and R.sub.5 are hydrogen, lower alkyl, trifluoromethyl, amino, mono- or di-lower alkylamino, heterocyclic amino, halogen or ##STR2## (in which R.sub.6 is hydrogen, lower alkyl or lower alkylsulfonyl, A is carbonyl or sulfonyl, and R.sub.7 is lower alkyl, halogenated lower alkyl, mono- or di-lower alkylamino, mono- or di-lower alkylaminoalkyl, unsubstituted phenyl or phenyl having halogen, lower alkyl, lower alkoxy or trifluoromethyl, phenylamino or phenylamino having halogen, lower alkyl, lower alkoxy or trifluoromethyl); and their pharmaceutically acceptable acid addition salts. These compounds are useful as agents for treating depression and depressive states.
REFERENCES:
patent: 3637731 (1972-01-01), Johnson
patent: 4172947 (1979-10-01), Warner et al.
patent: 4284641 (1981-08-01), Thorogood
patent: 4431815 (1984-02-01), Thorogood
Chemical Abstracts, 72: 1215293z (1970), [France 1,578,644, 8/14/69].
Fujimoto Takako
Saito Isao
Yamanaka Motosuke
Yamatsu Kiyomi
Eisai Co. Ltd.
Schwartz Richard A.
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