Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Parasitic organism or component thereof or substance...
Patent
1978-04-05
1980-07-01
Jiles, Henry R.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Parasitic organism or component thereof or substance...
424263, 542469, 544 96, 546196, 546197, 546225, 546269, 546270, 546328, A61K 31445, C07D40504
Patent
active
042106559
ABSTRACT:
Compounds of the class of (2-benzofuranyl)-1,2,3,6-tetrahydropyridines and (2-benzofuranyl)-piperidines which at the ring nitrogen atom are unsubstituted or substituted by a substituent of the class of certain aliphatic, cycloaliphatic and araliphatic radicals, and their pharmaceutically acceptable acid addition salts have valuable pharmacological properties. In particular, they inhibit monoamine oxidase and antagonize the action of tetrabenazine. They are useful as active ingredients for therapeutic compositions for the treatment of mental depression. Specific embodiments are 4-(2-benzofuranyl)-piperidine, 2-(5,6-dimethyl-2-benzofuranyl)-piperidine and their hydrochlorides.
REFERENCES:
patent: 3470192 (1969-09-01), Binon et al.
patent: 3890441 (1975-06-01), Schenker et al.
Ziegler, H., et al., Chim. Ther., 6, 159-166 (1971).
Bernasconi Raymond
Schenker Karl
Ciba-Geigy Corporation
Jiles Henry R.
Maitner John J.
Schwartz Richard A.
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