Anti-DCC gene product specific monoclonal antibody

Details Anti-DCC gene product specific monoclonal antibody Anti-DCC gene product specific monoclonal antibody

1993-06-24

1995-08-29

Scheiner, Toni R.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

436 64, 436813, 5303888, 53038885, G01N 33574

Patent

active

054459389

ABSTRACT:
This invention relates to monoclonal antibodies capable of specifically reacting with a peptide encoded by tumor suppressor gene DCC gene and to hybridomas capable of producing such monoclonal antibodies. In particular, the invention relates to mouse monoclonal antibody KM890 belonging to the IgG3 subclass, which is specifically reactive with a DCC gene DCC-2, and to a hybridoma KM890 capable of producing the monoclonal antibody KM890.
The monoclonal antibodies of this invention which are specifically reactive with DCC gene products can be used in immunohistochemical staining, quantitative determination of DCC gene products and the like, as well as in cancer diagnosis.

REFERENCES:
Boyd, J. et al., Proc Annu Meet Am Assoc Cancer Res, vol. 32, A 1838 1991.
Monoclonal Antibody Technology, Ailsa Campbell, Edited by R. H. Burdon, Elsevier, 1987, pp. 29-30.
The New England Journal of Medicine, vol. 319, No. 9, pp. 525-532.
Eur. J. Biochem., vol. 159, pp. 529-534 (1986).
Proc. Natl. Acad. Sci., USA, vol. 87, pp. 7555-7559 (1990).
Journal of Cell Science, vol. 101, 183-189 (1992).
Science, vol. 247, pp. 49-56, (1990).
Science, vol. 251, pp. 1366-1370 (1991).
Science, vol. 244, pp. 217-221 (1989).
Science, vol. 253, pp. 665-669 (1991).

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