Anti-cyanovirin antibody

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

5303894, C07K 1608

Patent

active

059985879

ABSTRACT:
The present invention provides antiviral proteins (collectively referred to as cyanovirins), conjugates thereof, DNA sequences ending such agents, host cells containing such DNA sequences, antibodies directed to such agents, compositions comprising such agents, and methods of obtaining and using such agents.

REFERENCES:
Bowie et al. Science 247:1306-1310, 1990.
Wells. Biochemistry 29:8509-8517, 1990.
Schultz et al. Principles of Protein Structure. Springer-Verlag, New York, pp. 14-16, 1979.
Abuchowski et al., "Soluble Polymer-Enzyme Adducts," in Enzymes as Drugs, Holcenberg et al., eds., John Wiley: New York, 1981, pp. 367-383.
Abuchowski et al., Alteration of Immunological Properties of Bovine Serum Albumin by Covalent Attachment of Polyethylene Glycol, Journal of Biological Chemistry, 252 (11), 3578-3581 (1977).
Aullo et al., "A Recombinant Diptheria Toxin Related Human CD4 Fusion Protein Specifically Kills HIV Infected Cells Which Express gp120 But Selects Fusion Toxin Resistant Cells Which Carry HIV," EMBO Journal, 11(2), 575-583 (1992).
Balter, "UN Readies New Global AIDS Plan," Science, 266, 1312-1313 (1994).
Banga et al., "Systemic Delivery of Therapeutic Peptides and Proteins," International Journal of Pharmaceutics, 48, 15-50 (1988).
Barry, "The Transdermal Route for Delivery of Peptides and Proteins," in Delivery Systems for Peptide Drugs, Davis et al., eds., Plenum Press: New York, 1986, pp. 265-275.
Berzofsky, "Approaches and Issues in the Development of Vaccines Against HIV," Journal of Acquired Immune Deficiency Syndromes, 4, 451-459 (1991).
Bird, "The Use of Spermicide Containing Nonoxynol-9 in the Prevention of HIV Infection," AIDS, 5(7), 791-796 (1991).
Bourinbaiar et al., "Anti-HIV Effect of Gramicidin In Vitro: Potential for Spermicide Use," Life Sciences, 54(1), 5-9 (1994).
Boyd, "Strategies for the Identification of New Agents for the Treatment of AIDS: A National Program to Facilitate the Discovery and Preclinical Development of New Drug Candidates for Clinical Evaluation," AIDS Etiology, Diagnosis, Treatment, and Prevention, Second Edition, DeVita et al., ed., J.B. Lippincott Company, 1988, pp. 305-317.
Boyd et al., "Anti-HIV Michellamines from Ancistrocladus korupensis," Journal of Medicinal Chemistry, 37(12), 1740-1745 (1994).
Capon et al., "Designing CD4 Immunoadhesins for AIDS Therapy," Nature, 337, 525-531 (1989).
Capon et al., "The CD4-gp120 Interaction and AIDS Pathogenesis," Annu. Rev. Immunol., 9, 649-678 (1991).
Carone et al., "Renal Tubular Processing of Small Peptide Hormones," The Journal of Laboratory and Clinical Medicine, 100(1), 1-14 (1982).
Carter et al., "Structure of Majusculaminde C, a Cyclic Depsipeptide from Lyngbya majuscula," J. Org. Chem., 49, 236-241 (1984).
Chaudhary et al., "Selective Killing of HIV-Infected Cells by Recombinant Human CD4-Pseudomonas Exotoxin Hybrid Protein," Nature, 335, 369-372 (1988).
Chaudhary et al., "CD4-PE40--A Chimeric Toxin Active Against Human Immunodeficiency Virus (HIV)-Infected Cells," The Human Retroviruses, pp. 379-387.
Coffin, John M., "HIV Population Dynamics In Vivo: Implications for Genetic Variation, Pathogenesis, and Therapy," Science, 267, 483-489 (1995).
Cohen, "High Turnover of HIV in Blood Revealed by New Studies," Science, 267, 179 (1995).
Coll et al., "The Application of Vacuum Liquid Chromatograph to the Separation of Terpene Mixtures," Journal of Natural Products, 49(5), 934-936 (1986).
Davey et al., "Use of Recombinant Soluble CD4 Pseudomonas Exotoxin, a Novel Immunotoxin, for Treatment of Persons Infected with Human Immunodeficiency Virus," Journal of Infectious Diseases, 170, 1180-1188 (1994).
Davis, "Delivery Systems for Bipharmaceuticals," J. Pharm. Pharmacol., 44(Suppl. 1), 186-190 (1992).
DeClercq, "Basic Approaches to Anti-Retroviral Treatment," Journal of Acquired Immune Deficiency Syndromes, 4(3), 207-218 (1991).
Deasy et al., in Microencapsulation and Related Processes, Swarbrick J., eds., Marcel Dekker, Inc.: New York, 1984, pp. 1-60.
Emtage, "Biotechnology and Protein Protein Production," in Delivery Systems for Peptide Drugs, Davis et al., eds., Plenum Press: New York, 1986, pp. 23-33.
Eppstein et al., "Alternative Delivery Systems for Peptides and Proteins as Drugs," CRC Critical Reviews in Therapeutic Drug Carrier Systems, 5(2), 99-139 (1988).
Faulkner, "Marine Natural Products," Natural Product Reports, pp. 355-394 (1994).
Frankmolle et al., "Antigfungal Cyclic Peptides from the Terrestrial Blue-Green Alga Anabaena laxa," The Journal of Antibiotics, 45(9), 1451-1457 (1992).
Freed et al., "The Role of the HIV Envelope Glycoproteins in Cell Fusion and the Pathogenesis of AIDS," Bull. Inst. Pasteur, 88, 73-110 (1990).
Glombitza et al., in Algal and Cyanobacterial Biotechnology, Cresswell, R.C., et al., eds., 1989, pp. 211-218.
Gulakowski et al., "A Semiautomated Multiparameter Approach for Anti-HIV Drug Screening," Journal of Virological Methods, 33, 87-100 (1991).
Gustafson et al., "A Nonpromoting Phorbol from the Samoan Medicinal Plant Homalanthus nutans Inhibits Cell Killing by HIV-1," J. Med. Chem., 35, 1978-1986 (1982).
Guyden, "Techniques for Gene Cloning and Expression," in Recombinant DNA Technology Concepts and Biomedical Applications, Steinberg et al., eds., Prentice Hall: Englewood Cliffs, NJ, 1993, pp. 81-124 and 150-162.
Husson et al., "Phase 1 Study of Continuous-Infusion Soluble CD4 as a Single Agent and In Combination with Oral Dideoxyinosine Therapy in Children with Symptomatic Human Immunodeficiency Virus Infection," The Journal of Pediatrics, 121(4), 627-633 (1992).
Kashman et al., "The Calanolides, a Novel HIV-Inhibitory Class of Coumarin Derivatives from the Tropical Rainforest Tree, Calophyllum lanigerum," Journal of Medicinal Chemistry, 35(15) 2735-2743 (1992).
Koenig et al., "Selective Infection of Human CD4+ Cells by Simian Immunodeficiency Virus: Productive Infection Associated with Envelope Glycoprotein-Induced Fusion," Proc. Natl. Acad. Sci. USA, 86, 2443-2447 (1989).
Krishnamurthy et al., "Structural Characterization of Toxic Cyclic Peptides from Blue-Green Algae by Tandem Mass Spectrometry," Proc. Natl. Acad. Sci. USA, 86, 770-774 (1989).
Laemmli, "Cleavage of Structural Proteins During the Assembly of the Head of Bacteriophage T4," Nature, 227, 680-685 (1970).
Langner, "Antiviral Effects of Different CD4-Immunoglobulin Constructs Against HIV-1 and SIV: Immunological Characterization, Pharmacokinetic Data and In Vivo Experiments," Arch. Virol., 130, 157-170 (1993).
Lin et al., "Selective Inhibition of Human Immunodeficiency Virus Type 1 Replication by the (-) but Not the (+) Enantiomer of Gossypol," Animicrob. Agents Chemother., 33(12), 2149-2151 (1989).
Lipton, "HIV Displays Its Coat of Arms," Nature, 367, 113-114 (1994).
Lisi et al., "Enzyme Therapy: I. Polyethylene Glycol:.beta.-Glucuronidase Conjugates as Potential Therapeutic Agents in Acid Mucopolysaccharidosis," J. Appl. Biochem., 4, 19-33 (1982).
Matsushita et al., "Characterization of a Human Immunodeficiency Virus Neutralizing Monoclonal Antibody and Mapping of the Neutralizing Epitope," Journal of Virology, 62(6), 2107-2114 (1988).
Maulding, "Prolonged Delivery of Peptides by Microcapsules," Journal of Controlled Release, 6, 167-176 (1987).
McCaffrey et al., "A Rapid Fluorometric DNA Assay for the Measurement of Cell Density and Proliferation In Vitro," In Vitro Cellular & Developmental Biology, 24(3), 247-252 (1988).
Merigan, "Treatment of AIDS with Combinations of Antiretroviral Agents," The American Journal of Medicine, 90(Supp. 4A), 8S-17S (1991).
Merson, "Slowing the Spread of HIV: Agenda for the 1990s" Science, 260, 1266-1268 (1993).
Michalowski et al., "A Novel Allophycocyanin Gene (apcD) from Cyanophora paradoxa Cyanelles," Nucleic Acids Research, 18(8), 2186 (1990).
Mitsuya et al., "Molecular Targets for AIDS Therapy," Science, 249, 1533-1544 (1990).
Moore et al., "Sensitive ELISA for the gp120 and gp160 Surface Glycoproteins of HIV-1," AIDS Research and Human Retroviruses, 4(5), 369-379 (1988).
Moore et al., "Virions of Primary Human Immunodeficiency Virus Type 1 Is

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Anti-cyanovirin antibody does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Anti-cyanovirin antibody, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Anti-cyanovirin antibody will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-825291

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.