Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Monoclonal antibody or fragment thereof
Patent
1997-03-27
2000-08-29
Chin, Christopher L.
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Monoclonal antibody or fragment thereof
424535, 424807, 435 722, 435 7021, 4351722, 435342, 5303886, 530822, 530832, A61K 39395, A61K 3520, C07K 1620, C12N 520
Patent
active
061104639
ABSTRACT:
Compositions and methods useful for conferring passive or active immunity to the parasite, C. parvum. A high molecular weight glycoprotein antigen isolated from C. parvum, capable of binding the mAb 3E2, was shown to harbor an epitope critical for triggering the neutralizing CSP-like reaction in the parasite. Antibodies targeted against the critical epitope were shown to possess neutralizing activity, and could be combined with other anti-C. parvum monoclonal antibodies and administered to an animal to confer passive immunity. Immunogenic compositions including the purified antigen are disclosed for use in stimulating an active immune response against C. parvum.
REFERENCES:
Riggs, M.W., Yount, P.A., Stone, A.L., Langer, R.C. (1996) Protective Monoclonal Antibodies Define a Distinct, Conserved Epitope on an Apical Complex Exoantigen of Cryptosporidium parvum Sporozoites. J. Euk. Microbiol. 43:74S-75S.
Langer, R.C., Riggs, M.W. (1996) Neutralizing Monoclonal Antibody Protects Against Cryptosporidium parvum Infection by Inhibiting Sporozoite Attachment and Invasion. J. Euk. Microbiol. 43:76S-77S.
Albert, M.M., Rusnak, J., Luther, M.F. and Graybill, J.R. (1994) Treatment of murine cryptosporidiosis with anti-cryptosporidial immune rat bile. Am. J. Trop. Med. Hyg., 50:112.
Arrowood, M.J., Mead, J.R., Mahrt, J.L. and Sterling, C.R. (1989) Effects of immune colostrum and orally administered antisporozoite monoclonal antibodies on the outcome of Cryptosporidium parvum infections in neonatal mice. Infect. Immun., 57:2283.
Arrowood, M.J., Sterling, C.R. and Healey, M.C. (1991) Immunofluorescent microscopical visualization of trails left by gliding Cryptosporidium parvum sporozoites. Parasitol., 77:315-317.
Bjorneby, J.M. Riggs, M.W. and Perryman, L.E. (1990) Cryptosporidium parvum merozoites share neutralization-sensitive epitopes with sporozoites. J. Immunol., 145:298-304.
Bjorneby, J.M., Hunsaker, B.D., Riggs, M.W. and Perryman, L.E. (1991) Monoclonal antibody immunotherapy in nude mice persistently infected with Cryptosporidium parvum. Infect. Immun., 59:1172.
Bonnin, A., Dubremetz, J.F. and Camerlynck, P. (1991) Characterization of microneme antigens of Cryptosporidium parvum. Infect. Immun., 59:1703.
Bonnin, A., Dubremetz, J.F. and Camerlynck, P. (1993) A new antigen of Cryptosporidium parvum micronemes possessing epitopes cross-reactive with macrogamete granules. Parasitol. Res., 79:8-14.
Bonnin, A., Gut, J., Dubremetz, J.F., Newlson, R. and Camerlynck, P. (1995) Monoclonal antibodies identify a subset of dense granules in Cryptosporidium parvum zoites and gamonts. J. Euk. Microbiol., 42:395.
Borowitz, S.M. and Saulsbury, F.T. (1991) Treatment of chronic cryptosporidial infection with orally administered human serum immune globulin. J. Pediatrics, 119:593.
Cama, V.A. and Sterling, C.R. (1991) Hyperimmune hens as a novel source of anti-Cryptosporidium antibodies suitable for passive immune transfer. J. Protozool., 38:42S.
Cho, M.-H. (1993) Passive transfer of immunity against Cryptosporidium infection in neonatal mice using monoclonal antibodies. Kor. J. Parasitol., 31:223-30.
Cochrane, A.H., Aikawa, M., Jeng, M. and Nussenzweig, R.S. (1976) Antibody-induced ultrastructural changes of malarial sporozoites. J. Immunol., 116:859.
Doyle, P.S., Crabb, J. and Petersen, C. (1993) Anti-Cryptosporidium parvum antibodies inhibit infectivity in vitro and in vivo. Infect. Immun., 61:4079.
Fayer, R., Perryman, L.E. and Riggs, M.W. (1989) Hyperimmune bovine colostrum neutralizes Cryptosporidium sporozoites and protects mice against oocyst challenge. J. Parasitol., 75:151.
Fayer, R., Andrews, C., Ungar, B.L.P. and Blagburn, B. (1989) Efficacy of hyperimmune bovine colostrum for prophylaxis of cryptosporidiosis in neonatal calves. J. Parasitol., 75:393.
Fayer, R. Guidry, A. and Blagburn, B.L. (1990) Immunotherapeutic efficacy of bovine colostral immunoglobulins from a hyperimmunized cow against cryptosporidiosis in neonatal mice. Infect. Immun., 58:2962.
Fayer, R., Tilley, M., Upton, S.J., Guidry, A.J., Thayer, D.W., Hildreth, M. and Thomson, S. (1991) Production and preparation of hyperimmune bovine colostrum for passive immunotherapy of cryptosporidiosis. J. Protozool., 38:38S.
Flanigan, T., Marshall, R., Redman, D., Kaetzel, C. and Ungar, B. (1991) In vitro screening of therapeutic agents against Cryptosporidium: hyperimmune cow colostrum is highly inhibitory. J. Protozool., 38:225S.
Flanigan, T.P. (1994) Human immunodeficiency virus infection and cryptosporidiosis: protective immune responses. Am. J. Trop. Med. Hyg., 50:29.
Flanigan, T.P., Wisnewski, A., Wiest, P.M., Johnson, J., Tzipori, S., Hamer, D., Lam, N. and Kresina, T.F. (1993) Human monoclonal antibodies against Cryptosporidium parvum generated by hypo-osmolar electrofusion. Trans. Assoc. Am. Phys. 106:86-90.
Gut, J. and Nelson, R.G. (1994) Cryptosporidium parvum sporozoites deposit trails of 11A5 antigen during gliding locomotion an shed 11A5 antigen during invasion of MDCK cells in vitro. J. Euk. Microbiol., 41:42S.
Harp, J.A. and Goff, J.P. (1995) Protection of calves with a vaccine against Cryptosporidium parvum. J. Parasitol., 81:54-7.
Hill, B.D., Dawson, A.M. and Blewett, D.A. (1993) Neutralisation of Cryptosporidium parvum sporozoites by immunoglobulin and nonimmunoglobulin components in serum. Res. Vet. Sci., 54:356.
Jenkins, M., Kerr, D., Fayer, R. and Wall, R. (1996) Serum and colostrum antibody responses induced by jet-injection of sheep with DNA encoding a Cryptosporidium parvum antigen. Vaccine. 13:1658-64.
Kuhls, T.L., Orlicek, S.L., Mosier, D.A., Crawford, D.L., Abrams, V.L. and Greenfield, R.A. (1995) Enteral human serum immunoglobulin treatment of cryptosporidiosis in mice with severe combined immunodeficiency. Infect. Immun., 63:3582-6.
Luft, B.J. Payne, D., Woodmansee, D. and Kim, C.W. (1987) Characterization of the Cryptosporidium antigens from sporulated oocysts of Cryptosporidium parvum. Infect. Immun., 55:2436.
McDonald, V., Deer, R.M.A., Nina, J.M.S., Wright, S., Chiodini, P.L. and McAdam, K.P.W.J. (1991) Characteristics and specificity of hybridoma antibodies against oocyst antigens of Cryptosporidium parvum from man. Parasite Immunol., 13:251.
McDonald, V., McCrossan, M.V. and Petry, F. (1995) Localization of parasite antigens in Cryptosporidium parvum infected epithelial cells using monoclonal antibodies. Parasitol., 110:259.
Mead, J.R., Arrowood, M.J. and Sterling, C.R. (1988) Antigens of Cryptosporidium sporozoites recognized by immune sera of infected animals and humans. J. Parasitol., 74:135-143.
Naciri, M. Mancassola, R. Reperant, J.M., Canivez, O., Quinique, B. and Yvore, P. (1994) Treatment of experimental ovine cryptosporidiosis with ovine and bovine hyperimmune colostrum. Vet. Parasitol., 53:173.
Nina, J.M.S., McDonald, V., Deer, R.M.A., Wright, S.E., Dyson, D.A., Chiodini, P.L. and McAdam, K.P.W.J. (1992) Comparative study of the antigenic composition of oocyst isolates of Cryptosporidium parvum from different hosts. Parasite Immunol., 14:227.
Nord, J., Ma, P., DiJohn, D., Tzipori, S. and Tacket, C.O. (1990) Treatment with bovine hyperimmune colostrum of cryptosporidial diarrhea in AIDS patients. AIDS. 4:581-4.
Perryman, L.E., Riggs, M.W., Mason, P.H. and Fayer, R. (1990) Kinetics of Cryptosporidium parvum sporozoite neutralization by monoclonal antibodies, immune bovine serum, and immune bovine colostrum. Infect. Immun., 58:257.
Perryman, L.E. and Bjorneby, J.M. (1991) Immunotherapy of cryptosporidiosis in immunodeficient animal models. J. Protozool, 38:98S.
Perryman, L.E., Kegerreis, K.A. and Mason, P.H. (1993) Effect of orally administered monoclonal antibody on persistent Cryptosporidium parvum infection in SCID mice. Infect. Immun., 61:4906-8.
Perryman, L.E., Jasmer, D.P., Riggs, M.W., Bohnet, S.G., McGuire, T.C. and Arrowood, M.J. (1996) A cloned gene of Cryptosporidium parvum encodes neutralization-sensitive epitopes. Mol. Biochem. Parasitol., 80:137-47.
Petersen, C., Gut, J., Nelson, R.G. and Leech, J.H. (1991) Characteristics of a Cryptosporidium parvum sporozoite glycoprotein, J. Protoz
Perryman Lance E.
Riggs Michael W.
Chin Christopher L.
Grun James L.
North Carolina State University
The Arizona Board of Regents
LandOfFree
Anti-Cryptosporidium parvum preparations does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Anti-Cryptosporidium parvum preparations, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Anti-Cryptosporidium parvum preparations will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1246706