Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Catalytic antibody
Reexamination Certificate
2005-07-05
2005-07-05
Patterson, Jr., Charles L. (Department: 1652)
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Catalytic antibody
C424S094100
Reexamination Certificate
active
06913917
ABSTRACT:
Disclosed are catalytic antibodies and polypeptides capable of degrading cocaine. Said catalytic antibodies and polypeptides are characterized by the amino acid sequence of their complementary determining regions and framework regions. The present invention also discloses a pharmaceutical composition and a method for decreasing the concentration and a method for decreasing the concentration of cocaine of a subject. Finally, the invention discloses pharmaceutical compositions and methods for treating cocaine overdose and addiction in subjects.
REFERENCES:
patent: 3888866 (1975-06-01), Leute et al.
patent: 3917582 (1975-11-01), Soffer et al.
patent: 3975237 (1976-08-01), Rubenstein et al.
patent: 4045420 (1977-08-01), Soffer et al.
patent: 4197237 (1980-04-01), Leute et al.
patent: 4203802 (1980-05-01), Rubenstein et al.
patent: 4235864 (1980-11-01), Kaul et al.
patent: 4659567 (1987-04-01), Tramontano et al.
patent: 4792446 (1988-12-01), Kim et al.
patent: 4963355 (1990-10-01), Kim et al.
patent: 5030717 (1991-07-01), Tramontano et al.
patent: 5079152 (1992-01-01), Benkovic et al.
patent: 5202270 (1993-04-01), Ungemach et al.
patent: 5463028 (1995-10-01), Landry et al.
patent: 5948658 (1999-09-01), Landry
patent: 5977314 (1999-11-01), Landry et al.
patent: 5990285 (1999-11-01), Landry et al.
patent: WO 9320076 (1993-10-01), None
Abraham, et al., “N-Modified Analogues of Cocaine: Synthesis and Inhibition of Binding to the Cocaine Receptor,”J. Med. Chem., 35: 141-144 (1992).
Ambre, J., et al., “Urinary excretion of ecgonine methyl ester, a major metabolite of cocaine in humans,”J. Anal. Toxicol., 8:23-25 (1984).
Ambre, J., “The urinary excretion of cocaine and metabolites in humans: a kinetic analysis of published data,”J. Anal. Toxicol., 9:241-245 (1985).
Chandrakumar, et al., “Phenylphosphonate monoester analogs of cocaine,”Bioorg.&Medic. Chem. Let., 3:309-312 (1993).
Landry, et al., “Antibody-Catalyzed Degradation of Cocaine,”Science, 259:1899-1901 (1993).
Lewin, et al., “2 beta-substituted Analogues of Cocaine Synthesis and Inhibition of Binding to the Cocaine. Receptor.”J. Med. Chem. 35:135-140 (1992).
Schultz, P.G., “The interplay between chemistry and biology in the design of enzymatic catalysts,”Science, 240:426-433 (1988).
Tramontano, et al., “Catalytic antibodies,”Science, 234:1566-1570 (1986).
Tramontano, et al., “Antibody catalysis approaching the activity of enzymes,”J. Am. Chem. Soc., 110:2282-2286 (1988).
Tramontano, et al., “Chemical reactivity at an antibody binding site elicited by mechanistic design of a synthetic antigen,”Proc. Natl. Acad. Sci. USA, 83:6736-6740 (1986).
Yang, et al., “Anti-Cocaine Catalytic Antibodies: A Synthetic Approach To Improved Antibody Diversity,”J. Am. Chem. Soc., 118: No. 25, 5881-5890 (1996).
Basmadjian et al. (1995) Generation of polyclonal catalytic antibodies against cocaine using transition state analogs of cocaine conjugated to Diphtheria toxoid, Chem. Pharm. Bull. 43(11) : 1902-1911.
Landry, Donald W. (1995) Anti-cocaine catalytic antibodies : A novel approach to addiction, Abstracts of Papers Am. Chem. Soc. 209, ANYL 19, Abstract No. XP000992924 ; and.
Landry et al. (1997) Anti-cocaine catalytic antibodies: A novel approach to the problem of addiction, J. Addict. Dis. 16(3) : 1-17.
Cooper & Dunham LLP
Patterson Jr. Charles L.
The Trustees of Columbia University in the City of New York
White, Esq. John P.
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