Anti-cocaine catalytic antibody

Details Anti-cocaine catalytic antibody Anti-cocaine catalytic antibody

1996-06-25

1999-09-07

Patterson, Jr., Charles L.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Catalytic antibody

C12N 900

Patent

active

059486589

ABSTRACT:
Disclosed are catalytic antibodies and polypeptides capable of degrading cocaine. Said catalytic antibodies and polypeptides are characterized by the amino acid sequence of their complementarity determining regions and framework regions. The present invention also discloses a pharmaceutical composition and a method for decreasing the concentration of cocaine in a subject. Finally, the invention discloses pharmaceutical compositions and methods for treating cocaine overdose and addiction in subjects.

REFERENCES:
patent: 3888866 (1975-06-01), Leute et al.
patent: 3917582 (1975-11-01), Soffer et al.
patent: 4045420 (1977-08-01), Soffer et al.
patent: 4197237 (1980-04-01), Leute et al.
patent: 4203802 (1980-05-01), Rubenstein et al.
patent: 4235864 (1980-11-01), Kaul et al.
patent: 4659567 (1987-04-01), Tramontano et al.
patent: 4792446 (1988-12-01), Kim et al.
patent: 4963355 (1990-10-01), Kim et al.
patent: 5030717 (1991-07-01), Tramontano et al.
patent: 5079152 (1992-01-01), Benkovic et al.
patent: 5202270 (1993-04-01), Ungemach et al.
patent: 5463028 (1995-10-01), Landry et al.
Yang, G., et. al. (1996) J. Am. Chem. Soc. 118, 5881-5890.
Landry, D.W., et. al. (1993) Science 259, 1899-1901.
Abraham, et al. (1992) "N-Modified Analogues of Cocaine: Synthesis and Inhibition of Binding to the Cocaine Receptor." J. Med. Chem. 35:141-144.
Ambre, J., et al. (1984), Urinary execretion of ecgonine methyl ester, a metabolite of cocaine in humans, J. Anal Toxicol., 8:23-.
Ambre, J., et al. (1985), The urinary execretion of cocaine and metabolites in humans: a kinetic analysis of published data, J. Anal., Toxicol., 9:241-245.
Chandrakumar, et al., (1993), Phenylphosphonate monoester analogs of cocaine, Bioorg. & Medic. Chem. Let., 3:309-312.
Landry, et al. (1993), "Antibody-Catalyzed Degradation of Cocaine." Science 259:1899-1901.
J. Med. Chem. 35:135-140.
Schultz, P.G., (1988), The interplay between chemistry and biology in the design of enzymatic catalysts, Science 240:426-433.
Tramontano, et al., (1986), Catalytic antibodies, Science, 234:1566-1570.
Tramontano, A., et al., (1988), Antibody catalysis approaching the activity of enzymes, J. Am. Chem. Soc., 110:2282-2286; and.
Tramontano, A., et al., (1986), Chemical reactivity at an antibody binding site elicited by mechanistic design of a synthetic anti-gen, Proc. Natl. Acad. Sci. USA, 83:6736-6740.

Affiliated with

Also associated with

Rating

Anti-cocaine catalytic antibody does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Anti-cocaine catalytic antibody, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Anti-cocaine catalytic antibody will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1803934