Anti-coagulants of the 4-hydroxycoumarin type and rodenticidal c

Details Anti-coagulants of the 4-hydroxycoumarin type and rodenticidal c Anti-coagulants of the 4-hydroxycoumarin type and rodenticidal c

1983-06-14

1985-05-28

Milestone, Norma S.

Drug, bio-affecting and body treating compositions

Identification or warning feature

Taste or smell or chemical irritation to the eye, nose, or...

424 84, 514822, 514337, 514457, 546269, 549285, 568327, 568306, 568705, 568808, 260465R, 260465F, A01N 4316, A01N 2508, A01N 2500, C07D31156

Patent

active

045200076

ABSTRACT:
Compounds having blood-anticoagulant properties of the general molecular formula: ##STR1## in which Z represents a halogen atom, preferably a chlorine atom, and n is 0, 1 or 2 and R.sup.4 represents either (1) a grouping which comprises a phenylene radical attached directly or indirectly to the tetralin ring and having in the para position (with respect to such attachment) an electron-withdrawing atom or group whose rotational volume substantially does not exceed that of a phenyl group and which forms together with said phenylene radical a polarizable structure, or (2) a grouping selected from: ##STR2## or (3) a grouping which comprises a phenylene radical attached directly to the tetralin ring and having in the para position (with respect to such attachment) a substituted furanyl or thiophenyl radical attached thereto directly or through oxygen and/or methylene, said furanyl or thiophenyl radical having such an electron-withdrawing atom or group as a substituent in a position forming with the furanyl or thiophenyl radical a polarizable structure, compounds of the type (1) in which R.sup.4 contains two phenylene radicals linked essentially linearly by an aliphatic chain comprising a methylene radical or radicals and optionally at least one oxygen or sulphur atom being preferred.
Also included are the processes for the preparation of such compound; rodenticidal compositions containing them; and a method for controlling rodents by applying such a composition.

REFERENCES:
patent: 3764693 (1973-10-01), Boschetti et al.
patent: 3957824 (1976-05-01), Hadler et al.
patent: 4009022 (1977-02-01), Fujimoto
patent: 4035505 (1977-07-01), Hadler et al.
B. Miller, J. Org. Chem., 42, (8), 1408-1415, (1977).
Hadler et al., Nature, 253, pp. 275-277, (1975).

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